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DNA methylation regulates the neonatal CD4+ T-cell response to pneumonia in mice.
McGrath-Morrow SA, Ndeh R, Helmin KA, Chen SY, Anekalla KR, Abdala-Valencia H, D'Alessio FR, Collaco JM, Singer BD. McGrath-Morrow SA, et al. Among authors: singer bd. J Biol Chem. 2018 Jul 27;293(30):11772-11783. doi: 10.1074/jbc.RA118.003589. Epub 2018 Jun 4. J Biol Chem. 2018. PMID: 29866884 Free PMC article.
TET2 coactivates gene expression through demethylation of enhancers.
Wang L, Ozark PA, Smith ER, Zhao Z, Marshall SA, Rendleman EJ, Piunti A, Ryan C, Whelan AL, Helmin KA, Morgan MA, Zou L, Singer BD, Shilatifard A. Wang L, et al. Among authors: singer bd. Sci Adv. 2018 Nov 7;4(11):eaau6986. doi: 10.1126/sciadv.aau6986. eCollection 2018 Nov. Sci Adv. 2018. PMID: 30417100 Free PMC article.
CATACOMB: An endogenous inducible gene that antagonizes H3K27 methylation activity of Polycomb repressive complex 2 via an H3K27M-like mechanism.
Piunti A, Smith ER, Morgan MAJ, Ugarenko M, Khaltyan N, Helmin KA, Ryan CA, Murray DC, Rickels RA, Yilmaz BD, Rendleman EJ, Savas JN, Singer BD, Bulun SE, Shilatifard A. Piunti A, et al. Among authors: singer bd. Sci Adv. 2019 Jul 3;5(7):eaax2887. doi: 10.1126/sciadv.aax2887. eCollection 2019 Jul. Sci Adv. 2019. PMID: 31281901 Free PMC article.
Uncoupling histone H3K4 trimethylation from developmental gene expression via an equilibrium of COMPASS, Polycomb and DNA methylation.
Douillet D, Sze CC, Ryan C, Piunti A, Shah AP, Ugarenko M, Marshall SA, Rendleman EJ, Zha D, Helmin KA, Zhao Z, Cao K, Morgan MA, Singer BD, Bartom ET, Smith ER, Shilatifard A. Douillet D, et al. Among authors: singer bd. Nat Genet. 2020 Jun;52(6):615-625. doi: 10.1038/s41588-020-0618-1. Epub 2020 May 11. Nat Genet. 2020. PMID: 32393859 Free PMC article.
The lung microenvironment shapes a dysfunctional response of alveolar macrophages in aging.
McQuattie-Pimentel AC, Ren Z, Joshi N, Watanabe S, Stoeger T, Chi M, Lu Z, Sichizya L, Aillon RP, Chen CI, Soberanes S, Chen Z, Reyfman PA, Walter JM, Anekalla KR, Davis JM, Helmin KA, Runyan CE, Abdala-Valencia H, Nam K, Meliton AY, Winter DR, Morimoto RI, Mutlu GM, Bharat A, Perlman H, Gottardi CJ, Ridge KM, Chandel NS, Sznajder JI, Balch WE, Singer BD, Misharin AV, Budinger GRS. McQuattie-Pimentel AC, et al. Among authors: singer bd. J Clin Invest. 2021 Feb 15;131(4):e140299. doi: 10.1172/JCI140299. J Clin Invest. 2021. PMID: 33586677 Free PMC article.
AMP-activated protein kinase is necessary for Treg cell functional adaptation to microenvironmental stress.
Torres Acosta MA, Mambetsariev N, Reyes Flores CP, Helmin KA, Liu Q, Joudi AM, Morales-Nebreda L, Gurkan J, Cheng K, Abdala-Valencia H, Weinberg SE, Singer BD. Torres Acosta MA, et al. Among authors: singer bd. bioRxiv [Preprint]. 2023 Dec 1:2023.11.29.568904. doi: 10.1101/2023.11.29.568904. bioRxiv. 2023. PMID: 38076988 Free PMC article. Preprint.
115 results