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Repeat treatment of organotypic airway cultures with ethyl methanesulfonate causes accumulation of somatic cell mutations without expansion of bronchial-carcinoma-specific cancer driver mutations.
Wang Y, Le Y, Harris KL, Chen Y, Li X, Faske J, Wynne RA, Mittelstaedt RA, Cao X, Miranda-Colon J, Elkins L, Muskhelishvili L, Davis K, Mei N, Sun W, Robison TW, Heflich RH, Parsons BL. Wang Y, et al. Among authors: harris kl. Mutat Res Genet Toxicol Environ Mutagen. 2024 Jul;897:503786. doi: 10.1016/j.mrgentox.2024.503786. Epub 2024 Jun 24. Mutat Res Genet Toxicol Environ Mutagen. 2024. PMID: 39054009
Ancestral Sequence Reconstruction of a Cytochrome P450 Family Involved in Chemical Defense Reveals the Functional Evolution of a Promiscuous, Xenobiotic-Metabolizing Enzyme in Vertebrates.
Harris KL, Thomson RES, Gumulya Y, Foley G, Carrera-Pacheco SE, Syed P, Janosik T, Sandinge AS, Andersson S, Jurva U, Bodén M, Gillam EMJ. Harris KL, et al. Mol Biol Evol. 2022 Jun 2;39(6):msac116. doi: 10.1093/molbev/msac116. Mol Biol Evol. 2022. PMID: 35639613 Free PMC article.
73 results