Tao H - Search Results

1

Discovery of New α-Glucosidase Inhibitors: Structure-Based Virtual Screening and Biological Evaluation.

Liu SK, Hao H, Bian Y, Ge YX, Lu S, Xie HX, Wang KM, Tao H, Yuan C, Zhang J, Zhang J, Jiang CS, Zhu K. Liu SK, et al. Among authors: tao h. Front Chem. 2021 Mar 8;9:639279. doi: 10.3389/fchem.2021.639279. eCollection 2021. Front Chem. 2021. PMID: 33763406 Free PMC article.

2

Discovery of New Selective Butyrylcholinesterase (BChE) Inhibitors with Anti-Aβ Aggregation Activity: Structure-Based Virtual Screening, Hit Optimization and Biological Evaluation.

Jiang CS, Ge YX, Cheng ZQ, Wang YY, Tao HR, Zhu K, Zhang H. Jiang CS, et al. Among authors: tao hr. Molecules. 2019 Jul 15;24(14):2568. doi: 10.3390/molecules24142568. Molecules. 2019. PMID: 31311169 Free PMC article.

3

Discovery of new potent protein arginine methyltransferase 5 (PRMT5) inhibitors by assembly of key pharmacophores from known inhibitors.

Zhu K, Song JL, Tao HR, Cheng ZQ, Jiang CS, Zhang H. Zhu K, et al. Among authors: tao hr. Bioorg Med Chem Lett. 2018 Dec 15;28(23-24):3693-3699. doi: 10.1016/j.bmcl.2018.10.026. Epub 2018 Oct 19. Bioorg Med Chem Lett. 2018. PMID: 30366617

4

Identification of a novel selective small-molecule inhibitor of protein arginine methyltransferase 5 (PRMT5) by virtual screening, resynthesis and biological evaluations.

Zhu K, Jiang C, Tao H, Liu J, Zhang H, Luo C. Zhu K, et al. Among authors: tao h. Bioorg Med Chem Lett. 2018 May 15;28(9):1476-1483. doi: 10.1016/j.bmcl.2018.03.087. Epub 2018 Mar 30. Bioorg Med Chem Lett. 2018. PMID: 29628326

5

Identification of 5-benzylidene-2-phenylthiazolones as potent PRMT5 inhibitors by virtual screening, structural optimization and biological evaluations.

Zhu K, Tao H, Song JL, Jin L, Zhang Y, Liu J, Chen Z, Jiang CS, Luo C, Zhang H. Zhu K, et al. Among authors: tao h. Bioorg Chem. 2018 Dec;81:289-298. doi: 10.1016/j.bioorg.2018.08.021. Epub 2018 Aug 20. Bioorg Chem. 2018. PMID: 30172110

6

Discovery of Novel PRMT5 Inhibitors by Virtual Screening and Biological Evaluations.

Tao H, Yan X, Zhu K, Zhang H. Tao H, et al. Chem Pharm Bull (Tokyo). 2019;67(4):382-388. doi: 10.1248/cpb.c18-00980. Chem Pharm Bull (Tokyo). 2019. PMID: 30930442 Free article.

7

Interaction assessments of the first S-adenosylmethionine competitive inhibitor and the essential interacting partner methylosome protein 50 with protein arginine methyltransferase 5 by combined computational methods.

Zhu K, Jiang CS, Hu J, Liu X, Yan X, Tao H, Luo C, Zhang H. Zhu K, et al. Among authors: tao h. Biochem Biophys Res Commun. 2018 Jan 1;495(1):721-727. doi: 10.1016/j.bbrc.2017.11.089. Epub 2017 Nov 14. Biochem Biophys Res Commun. 2018. PMID: 29154828

8

Discovery of 2-substituted-N-(3-(3,4-dihydroisoquinolin-2(1H)-yl)-2-hydroxypropyl)-1,2,3,4-tetrahydroisoquinoline-6-carboxamide as potent and selective protein arginine methyltransferases 5 inhibitors: Design, synthesis and biological evaluation.

Shao J, Zhu K, Du D, Zhang Y, Tao H, Chen Z, Jiang H, Chen K, Luo C, Duan W. Shao J, et al. Among authors: tao h. Eur J Med Chem. 2019 Feb 15;164:317-333. doi: 10.1016/j.ejmech.2018.12.065. Epub 2018 Dec 26. Eur J Med Chem. 2019. PMID: 30605830

9

Identification and Assessments of Novel and Potent Small-Molecule Inhibitors of EED-EZH2 Interaction of Polycomb Repressive Complex 2 by Computational Methods and Biological Evaluations.

Zhu K, Du D, Yang R, Tao H, Zhang H. Zhu K, et al. Among authors: tao h. Chem Pharm Bull (Tokyo). 2020 Jan 1;68(1):58-63. doi: 10.1248/cpb.c19-00550. Epub 2019 Nov 1. Chem Pharm Bull (Tokyo). 2020. PMID: 31685780 Free article.

10

Rational Design, synthesis and biological evaluation of novel triazole derivatives as potent and selective PRMT5 inhibitors with antitumor activity.

Zhu K, Shao J, Tao H, Yan X, Luo C, Zhang H, Duan W. Zhu K, et al. Among authors: tao h. J Comput Aided Mol Des. 2019 Aug;33(8):775-785. doi: 10.1007/s10822-019-00214-y. Epub 2019 Jul 16. J Comput Aided Mol Des. 2019. PMID: 31312965

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