Guan Y - Search Results

1

Manganese salts function as potent adjuvants.

Zhang R, Wang C, Guan Y, Wei X, Sha M, Yi M, Jing M, Lv M, Guo W, Xu J, Wan Y, Jia XM, Jiang Z. Zhang R, et al. Among authors: guan y. Cell Mol Immunol. 2021 May;18(5):1222-1234. doi: 10.1038/s41423-021-00669-w. Epub 2021 Mar 25. Cell Mol Immunol. 2021. PMID: 33767434 Free PMC article.

2

Manganese is critical for antitumor immune responses via cGAS-STING and improves the efficacy of clinical immunotherapy.

Lv M, Chen M, Zhang R, Zhang W, Wang C, Zhang Y, Wei X, Guan Y, Liu J, Feng K, Jing M, Wang X, Liu YC, Mei Q, Han W, Jiang Z. Lv M, et al. Among authors: guan y. Cell Res. 2020 Nov;30(11):966-979. doi: 10.1038/s41422-020-00395-4. Epub 2020 Aug 24. Cell Res. 2020. PMID: 32839553 Free PMC article. Clinical Trial.

3

Manganese Increases the Sensitivity of the cGAS-STING Pathway for Double-Stranded DNA and Is Required for the Host Defense against DNA Viruses.

Wang C, Guan Y, Lv M, Zhang R, Guo Z, Wei X, Du X, Yang J, Li T, Wan Y, Su X, Huang X, Jiang Z. Wang C, et al. Among authors: guan y. Immunity. 2018 Apr 17;48(4):675-687.e7. doi: 10.1016/j.immuni.2018.03.017. Epub 2018 Apr 10. Immunity. 2018. PMID: 29653696 Free article.

4

Golgi apparatus-synthesized sulfated glycosaminoglycans mediate polymerization and activation of the cGAMP sensor STING.

Fang R, Jiang Q, Guan Y, Gao P, Zhang R, Zhao Z, Jiang Z. Fang R, et al. Among authors: guan y. Immunity. 2021 May 11;54(5):962-975.e8. doi: 10.1016/j.immuni.2021.03.011. Epub 2021 Apr 14. Immunity. 2021. PMID: 33857420 Free article.

5

MAVS activates TBK1 and IKKε through TRAFs in NEMO dependent and independent manner.

Fang R, Jiang Q, Zhou X, Wang C, Guan Y, Tao J, Xi J, Feng JM, Jiang Z. Fang R, et al. Among authors: guan y. PLoS Pathog. 2017 Nov 10;13(11):e1006720. doi: 10.1371/journal.ppat.1006720. eCollection 2017 Nov. PLoS Pathog. 2017. PMID: 29125880 Free PMC article.

6

Mn²⁺ Directly Activates cGAS and Structural Analysis Suggests Mn²⁺ Induces a Noncanonical Catalytic Synthesis of 2'3'-cGAMP.

Zhao Z, Ma Z, Wang B, Guan Y, Su XD, Jiang Z. Zhao Z, et al. Among authors: guan y. Cell Rep. 2020 Aug 18;32(7):108053. doi: 10.1016/j.celrep.2020.108053. Cell Rep. 2020. PMID: 32814054 Free article.

7

Activation of STAT6 by STING is critical for antiviral innate immunity.

Chen H, Sun H, You F, Sun W, Zhou X, Chen L, Yang J, Wang Y, Tang H, Guan Y, Xia W, Gu J, Ishikawa H, Gutman D, Barber G, Qin Z, Jiang Z. Chen H, et al. Among authors: guan y. Cell. 2011 Oct 14;147(2):436-46. doi: 10.1016/j.cell.2011.09.022. Cell. 2011. PMID: 22000020 Free article.

8

Kupffer cell restoration after partial hepatectomy is mainly driven by local cell proliferation in IL-6-dependent autocrine and paracrine manners.

Ait Ahmed Y, Fu Y, Rodrigues RM, He Y, Guan Y, Guillot A, Ren R, Feng D, Hidalgo J, Ju C, Lafdil F, Gao B. Ait Ahmed Y, et al. Among authors: guan y. Cell Mol Immunol. 2021 Sep;18(9):2165-2176. doi: 10.1038/s41423-021-00731-7. Epub 2021 Jul 19. Cell Mol Immunol. 2021. PMID: 34282300 Free PMC article.

9

NLRP6 self-assembles into a linear molecular platform following LPS binding and ATP stimulation.

Leng F, Yin H, Qin S, Zhang K, Guan Y, Fang R, Wang H, Li G, Jiang Z, Sun F, Wang DC, Xie C. Leng F, et al. Among authors: guan y. Sci Rep. 2020 Jan 13;10(1):198. doi: 10.1038/s41598-019-57043-0. Sci Rep. 2020. PMID: 31932628 Free PMC article.

10

E-Selectin-Dependent Inflammation and Lipolysis in Adipose Tissue Exacerbate Steatosis-to-NASH Progression via S100A8/9.

Rodrigues RM, He Y, Hwang S, Bertola A, Mackowiak B, Ahmed YA, Seo W, Ma J, Wang X, Park SH, Guan Y, Fu Y, Vanhaecke T, Feng D, Gao B. Rodrigues RM, et al. Among authors: guan y. Cell Mol Gastroenterol Hepatol. 2022;13(1):151-171. doi: 10.1016/j.jcmgh.2021.08.002. Epub 2021 Aug 11. Cell Mol Gastroenterol Hepatol. 2022. PMID: 34390865 Free PMC article.

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