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A simulation study of the impact of drug-IKr binding mechanisms on biomarkers of proarrhythmic risk reveals a crucial role in reverse use-dependence of action potential duration and a marked influence on the vulnerable window.
Gomis-Tena J, Escobar F, Romero L. Gomis-Tena J, et al. Among authors: escobar f. Comput Methods Programs Biomed. 2024 Dec 18;260:108566. doi: 10.1016/j.cmpb.2024.108566. Online ahead of print. Comput Methods Programs Biomed. 2024. PMID: 39709744 Free article.
196 results