O'Brien ER - Search Results

1

HSP25 Vaccination Attenuates Atherogenesis via Upregulation of LDLR Expression, Lowering of PCSK9 Levels and Curbing of Inflammation.

Chen YX, Shi C, Deng J, Diao C, Maarouf N, Rosin M, Shrivastava V, Hu AA, Bharadwa S, Adijiang A, Ulke-Lemee A, Gwilym B, Hellmich A, Malozzi C, Batulan Z, Dean JLE, Ramirez FD, Liu J, Gerthoffer WT, O'Brien ER. Chen YX, et al. Among authors: o brien er. Arterioscler Thromb Vasc Biol. 2021 Jun;41(6):e338-e353. doi: 10.1161/ATVBAHA.121.315933. Epub 2021 Apr 1. Arterioscler Thromb Vasc Biol. 2021. PMID: 33792343 Free PMC article.

2

Unlike estrogens that increase PCSK9 levels post-menopause HSP27 vaccination lowers cholesterol levels and atherogenesis due to divergent effects on PCSK9 and LDLR.

Maarouf N, Chen YX, Shi C, Deng J, Diao C, Rosin M, Shrivastava V, Batulan Z, Liu J, O'Brien ER. Maarouf N, et al. Among authors: o brien er. Pharmacol Res. 2020 Nov;161:105222. doi: 10.1016/j.phrs.2020.105222. Epub 2020 Oct 3. Pharmacol Res. 2020. PMID: 33022407

3

Heat shock protein 27-derived atheroprotection involves reverse cholesterol transport that is dependent on GM-CSF to maintain ABCA1 and ABCG1 expression in ApoE^-/- mice.

Pulakazhi Venu VK, Adijiang A, Seibert T, Chen YX, Shi C, Batulan Z, O'Brien ER. Pulakazhi Venu VK, et al. FASEB J. 2017 Jun;31(6):2364-2379. doi: 10.1096/fj.201601188R. Epub 2017 Feb 23. FASEB J. 2017. PMID: 28232480

4

Characterization of heat shock protein 27 in extracellular vesicles: a potential anti-inflammatory therapy.

Shi C, Ulke-Lemée A, Deng J, Batulan Z, O'Brien ER. Shi C, et al. FASEB J. 2019 Feb;33(2):1617-1630. doi: 10.1096/fj.201800987R. Epub 2018 Sep 6. FASEB J. 2019. PMID: 30188755

5

Biophysical analyses and functional implications of the interaction between Heat Shock Protein 27 and antibodies to HSP27.

Chiu MH, Shi C, Rosin M, Batulan Z, O'Brien ER. Chiu MH, et al. Biochim Biophys Acta Gen Subj. 2019 Oct;1863(10):1536-1546. doi: 10.1016/j.bbagen.2019.05.016. Epub 2019 May 25. Biochim Biophys Acta Gen Subj. 2019. PMID: 31136785

6

Heat shock protein 27 immune complex altered signaling and transport (ICAST): Novel mechanisms of attenuating inflammation.

Shi C, Deng J, Chiu M, Chen YX, O'Brien ER. Shi C, et al. Among authors: o brien er. FASEB J. 2020 Nov;34(11):14287-14301. doi: 10.1096/fj.202001389RR. Epub 2020 Sep 4. FASEB J. 2020. PMID: 32888229

7

Heat shock protein 27 protects against atherogenesis via an estrogen-dependent mechanism: role of selective estrogen receptor beta modulation.

Rayner K, Sun J, Chen YX, McNulty M, Simard T, Zhao X, Wells DJ, de Belleroche J, O'Brien ER. Rayner K, et al. Arterioscler Thromb Vasc Biol. 2009 Nov;29(11):1751-6. doi: 10.1161/ATVBAHA.109.193656. Epub 2009 Sep 3. Arterioscler Thromb Vasc Biol. 2009. PMID: 19729610

8

Ethyl isopropyl amiloride inhibits smooth muscle cell proliferation and migration by inducing apoptosis and antagonizing urokinase plasminogen activator activity.

Chen YX, O'Brien ER. Chen YX, et al. Can J Physiol Pharmacol. 2003 Jul;81(7):730-9. doi: 10.1139/y03-066. Can J Physiol Pharmacol. 2003. PMID: 12897821

9

Heat shock protein-27 attenuates foam cell formation and atherogenesis by down-regulating scavenger receptor-A expression via NF-κB signaling.

Raizman JE, Chen YX, Seibert T, Hibbert B, Cuerrier CM, Salari S, Zhao X, Hu T, Shi C, Ma X, Simard T, Caravaggio J, Rayner K, Bowdish D, Moore K, O'Brien ER. Raizman JE, et al. Biochim Biophys Acta. 2013 Dec;1831(12):1721-8. doi: 10.1016/j.bbalip.2013.07.015. Epub 2013 Aug 11. Biochim Biophys Acta. 2013. PMID: 23939398

10

4-Phenylbutyrate protects against atherosclerotic lesion growth by increasing the expression of HSP25 in macrophages and in the circulation of Apoe^-/- mice.

Lynn EG, Lhoták Š, Lebeau P, Byun JH, Chen J, Platko K, Shi C, O'Brien ER, Austin RC. Lynn EG, et al. FASEB J. 2019 Jul;33(7):8406-8422. doi: 10.1096/fj.201802293RR. Epub 2019 Apr 9. FASEB J. 2019. PMID: 30964709

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