Kladwang W - Search Results

1

Combinatorial optimization of mRNA structure, stability, and translation for RNA-based therapeutics.

Leppek K, Byeon GW, Kladwang W, Wayment-Steele HK, Kerr CH, Xu AF, Kim DS, Topkar VV, Choe C, Rothschild D, Tiu GC, Wellington-Oguri R, Fujii K, Sharma E, Watkins AM, Nicol JJ, Romano J, Tunguz B, Participants E, Barna M, Das R. Leppek K, et al. Among authors: kladwang w. bioRxiv [Preprint]. 2021 Mar 30:2021.03.29.437587. doi: 10.1101/2021.03.29.437587. bioRxiv. 2021. Update in: Nat Commun. 2022 Mar 22;13(1):1536. doi: 10.1038/s41467-022-28776-w PMID: 33821271 Free PMC article. Updated. Preprint.

2

A mutate-and-map strategy for inferring base pairs in structured nucleic acids: proof of concept on a DNA/RNA helix.

Kladwang W, Das R. Kladwang W, et al. Biochemistry. 2010 Sep 7;49(35):7414-6. doi: 10.1021/bi101123g. Biochemistry. 2010. PMID: 20677780

3

A mutate-and-map strategy accurately infers the base pairs of a 35-nucleotide model RNA.

Kladwang W, Cordero P, Das R. Kladwang W, et al. RNA. 2011 Mar;17(3):522-34. doi: 10.1261/rna.2516311. Epub 2011 Jan 14. RNA. 2011. PMID: 21239468 Free PMC article.

4

Understanding the errors of SHAPE-directed RNA structure modeling.

Kladwang W, VanLang CC, Cordero P, Das R. Kladwang W, et al. Biochemistry. 2011 Sep 20;50(37):8049-56. doi: 10.1021/bi200524n. Epub 2011 Aug 25. Biochemistry. 2011. PMID: 21842868 Free PMC article.

5

A two-dimensional mutate-and-map strategy for non-coding RNA structure.

Kladwang W, VanLang CC, Cordero P, Das R. Kladwang W, et al. Nat Chem. 2011 Oct 30;3(12):954-62. doi: 10.1038/nchem.1176. Nat Chem. 2011. PMID: 22109276 Free PMC article.

6

An enumerative stepwise ansatz enables atomic-accuracy RNA loop modeling.

Sripakdeevong P, Kladwang W, Das R. Sripakdeevong P, et al. Among authors: kladwang w. Proc Natl Acad Sci U S A. 2011 Dec 20;108(51):20573-8. doi: 10.1073/pnas.1106516108. Epub 2011 Dec 5. Proc Natl Acad Sci U S A. 2011. PMID: 22143768 Free PMC article.

7

Automated RNA structure prediction uncovers a kink-turn linker in double glycine riboswitches.

Kladwang W, Chou FC, Das R. Kladwang W, et al. J Am Chem Soc. 2012 Jan 25;134(3):1404-7. doi: 10.1021/ja2093508. Epub 2012 Jan 12. J Am Chem Soc. 2012. PMID: 22192063

8

Ultraviolet shadowing of RNA can cause significant chemical damage in seconds.

Kladwang W, Hum J, Das R. Kladwang W, et al. Sci Rep. 2012;2:517. doi: 10.1038/srep00517. Epub 2012 Jul 18. Sci Rep. 2012. PMID: 22816040 Free PMC article.

9

Quantitative dimethyl sulfate mapping for automated RNA secondary structure inference.

Cordero P, Kladwang W, VanLang CC, Das R. Cordero P, et al. Among authors: kladwang w. Biochemistry. 2012 Sep 11;51(36):7037-9. doi: 10.1021/bi3008802. Epub 2012 Aug 29. Biochemistry. 2012. PMID: 22913637 Free PMC article.

10

Massively parallel RNA chemical mapping with a reduced bias MAP-seq protocol.

Seetin MG, Kladwang W, Bida JP, Das R. Seetin MG, et al. Among authors: kladwang w. Methods Mol Biol. 2014;1086:95-117. doi: 10.1007/978-1-62703-667-2_6. Methods Mol Biol. 2014. PMID: 24136600

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