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An oral non-covalent non-peptidic inhibitor of SARS-CoV-2 Mpro ameliorates viral replication and pathogenesis in vivo.
Zhou NE, Tang S, Bian X, Parai MK, Krieger IV, Flores A, Jaiswal PK, Bam R, Wood JL, Shi Z, Stevens LJ, Scobey T, Diefenbacher MV, Moreira FR, Baric TJ, Acharya A, Shin J, Rathi MM, Wolff KC, Riva L, Bakowski MA, McNamara CW, Catanzaro NJ, Graham RL, Schultz DC, Cherry S, Kawaoka Y, Halfmann PJ, Baric RS, Denison MR, Sheahan TP, Sacchettini JC. Zhou NE, et al. Among authors: scobey t. Cell Rep. 2024 Nov 26;43(11):114929. doi: 10.1016/j.celrep.2024.114929. Epub 2024 Nov 5. Cell Rep. 2024. PMID: 39504242 Free article.
Hybrid immunity to SARS-CoV-2 arises from serological recall of IgG antibodies distinctly imprinted by infection or vaccination.
Voss WN, Mallory MA, Byrne PO, Marchioni JM, Knudson SA, Powers JM, Leist SR, Dadonaite B, Townsend DR, Kain J, Huang Y, Satterwhite E, Castillo IN, Mattocks M, Paresi C, Munt JE, Scobey T, Seeger A, Premkumar L, Bloom JD, Georgiou G, McLellan JS, Baric RS, Lavinder JJ, Ippolito GC. Voss WN, et al. Among authors: scobey t. Cell Rep Med. 2024 Aug 20;5(8):101668. doi: 10.1016/j.xcrm.2024.101668. Epub 2024 Aug 1. Cell Rep Med. 2024. PMID: 39094579 Free PMC article.
The small molecule inhibitor of SARS-CoV-2 3CLpro EDP-235 prevents viral replication and transmission in vivo.
Rhodin MHJ, Reyes AC, Balakrishnan A, Bisht N, Kelly NM, Gibbons JS, Lloyd J, Vaine M, Cressey T, Crepeau M, Shen R, Manalo N, Castillo J, Levene RE, Leonard D, Zang T, Jiang L, Daniels K, Cox RM, Lieber CM, Wolf JD, Plemper RK, Leist SR, Scobey T, Baric RS, Wang G, Goodwin B, Or YS. Rhodin MHJ, et al. Among authors: scobey t. Nat Commun. 2024 Aug 1;15(1):6503. doi: 10.1038/s41467-024-50931-8. Nat Commun. 2024. PMID: 39090095 Free PMC article.
Hybrid immunity to SARS-CoV-2 arises from serological recall of IgG antibodies distinctly imprinted by infection or vaccination.
Voss WN, Mallory MA, Byrne PO, Marchioni JM, Knudson SA, Powers JM, Leist SR, Dadonaite B, Townsend DR, Kain J, Huang Y, Satterwhite E, Castillo IN, Mattocks M, Paresi C, Munt JE, Scobey T, Seeger A, Premkumar L, Bloom JD, Georgiou G, McLellan JS, Baric RS, Lavinder JJ, Ippolito GC. Voss WN, et al. Among authors: scobey t. bioRxiv [Preprint]. 2024 Jan 23:2024.01.22.576742. doi: 10.1101/2024.01.22.576742. bioRxiv. 2024. Update in: Cell Rep Med. 2024 Aug 20;5(8):101668. doi: 10.1016/j.xcrm.2024.101668 PMID: 38545622 Free PMC article. Updated. Preprint.
Vaccine-mediated protection against Merbecovirus and Sarbecovirus challenge in mice.
Martinez DR, Schäfer A, Gavitt TD, Mallory ML, Lee E, Catanzaro NJ, Chen H, Gully K, Scobey T, Korategere P, Brown A, Smith L, Parks R, Barr M, Newman A, Bowman C, Powers JM, Soderblom EJ, Mansouri K, Edwards RJ, Baric RS, Haynes BF, Saunders KO. Martinez DR, et al. Among authors: scobey t. Cell Rep. 2023 Oct 31;42(10):113248. doi: 10.1016/j.celrep.2023.113248. Epub 2023 Oct 18. Cell Rep. 2023. PMID: 37858337 Free PMC article.
A MERS-CoV antibody neutralizes a pre-emerging group 2c bat coronavirus.
Tse LV, Hou YJ, McFadden E, Lee RE, Scobey TD, Leist SR, Martinez DR, Meganck RM, Schäfer A, Yount BL, Mascenik T, Powers JM, Randell SH, Zhang Y, Wang L, Mascola J, McLellan JS, Baric RS. Tse LV, et al. Among authors: scobey td. Sci Transl Med. 2023 Sep 27;15(715):eadg5567. doi: 10.1126/scitranslmed.adg5567. Epub 2023 Sep 27. Sci Transl Med. 2023. PMID: 37756379 Free PMC article.
Vaccine-mediated protection against merbecovirus and sarbecovirus challenge in mice.
Martinez DR, Schafer A, Gavitt TD, Mallory ML, Lee E, Catanzaro NJ, Chen H, Gully K, Scobey T, Korategere P, Brown A, Smith L, Parks R, Barr M, Newman A, Bowman C, Powers JM, Mansouri K, Edwards RJ, Baric RS, Haynes BF, Saunders KO. Martinez DR, et al. Among authors: scobey t. bioRxiv [Preprint]. 2023 May 23:2023.05.22.540829. doi: 10.1101/2023.05.22.540829. bioRxiv. 2023. Update in: Cell Rep. 2023 Oct 31;42(10):113248. doi: 10.1016/j.celrep.2023.113248 PMID: 37293083 Free PMC article. Updated. Preprint.
Broadly neutralizing antibodies against sarbecoviruses generated by immunization of macaques with an AS03-adjuvanted COVID-19 vaccine.
Feng Y, Yuan M, Powers JM, Hu M, Munt JE, Arunachalam PS, Leist SR, Bellusci L, Kim J, Sprouse KR, Adams LE, Sundaramurthy S, Zhu X, Shirreff LM, Mallory ML, Scobey TD, Moreno A, O'Hagan DT, Kleanthous H, Villinger FJ, Veesler D, King NP, Suthar MS, Khurana S, Baric RS, Wilson IA, Pulendran B. Feng Y, et al. Among authors: scobey td. Sci Transl Med. 2023 May 10;15(695):eadg7404. doi: 10.1126/scitranslmed.adg7404. Epub 2023 May 10. Sci Transl Med. 2023. PMID: 37163615 Free PMC article.
A live dengue virus vaccine carrying a chimeric envelope glycoprotein elicits dual DENV2-DENV4 serotype-specific immunity.
Young E, Yount B, Pantoja P, Henein S, Meganck RM, McBride J, Munt JE, Baric TJ, Zhu D, Scobey T, Dong S, Tse LV, Martinez MI, Burgos AG, Graham RL, White L, DeSilva A, Sariol CA, Baric RS. Young E, et al. Among authors: scobey t. Nat Commun. 2023 Mar 13;14(1):1371. doi: 10.1038/s41467-023-36702-x. Nat Commun. 2023. PMID: 36914616 Free PMC article.
41 results