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Inhibition of Staphylococcus aureus biofilm-forming functional amyloid by molecular tweezers.
Malishev R, Salinas N, Gibson J, Eden AB, Mieres-Perez J, Ruiz-Blanco YB, Malka O, Kolusheva S, Klärner FG, Schrader T, Sanchez-Garcia E, Wang C, Landau M, Bitan G, Jelinek R. Malishev R, et al. Among authors: wang c. Cell Chem Biol. 2021 Sep 16;28(9):1310-1320.e5. doi: 10.1016/j.chembiol.2021.03.013. Epub 2021 Apr 13. Cell Chem Biol. 2021. PMID: 33852903 Free PMC article.
Lysine-specific molecular tweezers are broad-spectrum inhibitors of assembly and toxicity of amyloid proteins.
Sinha S, Lopes DH, Du Z, Pang ES, Shanmugam A, Lomakin A, Talbiersky P, Tennstaedt A, McDaniel K, Bakshi R, Kuo PY, Ehrmann M, Benedek GB, Loo JA, Klärner FG, Schrader T, Wang C, Bitan G. Sinha S, et al. Among authors: wang c. J Am Chem Soc. 2011 Oct 26;133(42):16958-69. doi: 10.1021/ja206279b. Epub 2011 Sep 29. J Am Chem Soc. 2011. PMID: 21916458 Free PMC article.
Comparison of three amyloid assembly inhibitors: the sugar scyllo-inositol, the polyphenol epigallocatechin gallate, and the molecular tweezer CLR01.
Sinha S, Du Z, Maiti P, Klärner FG, Schrader T, Wang C, Bitan G. Sinha S, et al. Among authors: wang c. ACS Chem Neurosci. 2012 Jun 20;3(6):451-8. doi: 10.1021/cn200133x. Epub 2012 Mar 7. ACS Chem Neurosci. 2012. PMID: 22860214 Free PMC article.
B., Loo, J. A., Klarner, F. G., Schrader, T., Wang, C., and Bitan, G. (2011) Lysine-specific molecular tweezers are broad-spectrum inhibitors of assembly and toxicity of amyloid proteins. ...
B., Loo, J. A., Klarner, F. G., Schrader, T., Wang, C., and Bitan, G. (2011) Lysine-specific molecular tweezers are broad-spec …
Tranilast binds to aβ monomers and promotes aβ fibrillation.
Connors CR, Rosenman DJ, Lopes DH, Mittal S, Bitan G, Sorci M, Belfort G, Garcia A, Wang C. Connors CR, et al. Among authors: wang c. Biochemistry. 2013 Jun 11;52(23):3995-4002. doi: 10.1021/bi400426t. Epub 2013 May 31. Biochemistry. 2013. PMID: 23679559 Free PMC article.
Major Differences between the Self-Assembly and Seeding Behavior of Heparin-Induced and in Vitro Phosphorylated Tau and Their Modulation by Potential Inhibitors.
Despres C, Di J, Cantrelle FX, Li Z, Huvent I, Chambraud B, Zhao J, Chen J, Chen S, Lippens G, Zhang F, Linhardt R, Wang C, Klärner FG, Schrader T, Landrieu I, Bitan G, Smet-Nocca C. Despres C, et al. Among authors: wang c. ACS Chem Biol. 2019 Jun 21;14(6):1363-1379. doi: 10.1021/acschembio.9b00325. Epub 2019 May 15. ACS Chem Biol. 2019. PMID: 31046227 Free PMC article.
Covalent fragment inhibits intramembrane proteolysis.
Eden A, Zhao J, Xiao Y, Gibson J, Wang C. Eden A, et al. Among authors: wang c. Front Mol Biosci. 2022 Sep 7;9:958399. doi: 10.3389/fmolb.2022.958399. eCollection 2022. Front Mol Biosci. 2022. PMID: 36158579 Free PMC article.
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