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cGAS-STING Pathway Does Not Promote Autoimmunity in Murine Models of SLE.
Motwani M, McGowan J, Antonovitch J, Gao KM, Jiang Z, Sharma S, Baltus GA, Nickerson KM, Marshak-Rothstein A, Fitzgerald KA. Motwani M, et al. Front Immunol. 2021 Mar 29;12:605930. doi: 10.3389/fimmu.2021.605930. eCollection 2021. Front Immunol. 2021. PMID: 33854495 Free PMC article.
cGAS Micro-Manages Genotoxic Stress.
Motwani M, Fitzgerald KA. Motwani M, et al. Immunity. 2017 Oct 17;47(4):616-617. doi: 10.1016/j.immuni.2017.09.020. Immunity. 2017. PMID: 29045895 Free article.
Nitro-fatty acids are formed in response to virus infection and are potent inhibitors of STING palmitoylation and signaling.
Hansen AL, Buchan GJ, Rühl M, Mukai K, Salvatore SR, Ogawa E, Andersen SD, Iversen MB, Thielke AL, Gunderstofte C, Motwani M, Møller CT, Jakobsen AS, Fitzgerald KA, Roos J, Lin R, Maier TJ, Goldbach-Mansky R, Miner CA, Qian W, Miner JJ, Rigby RE, Rehwinkel J, Jakobsen MR, Arai H, Taguchi T, Schopfer FJ, Olagnier D, Holm CK. Hansen AL, et al. Among authors: motwani m. Proc Natl Acad Sci U S A. 2018 Aug 14;115(33):E7768-E7775. doi: 10.1073/pnas.1806239115. Epub 2018 Jul 30. Proc Natl Acad Sci U S A. 2018. PMID: 30061387 Free PMC article.
Nrf2 negatively regulates STING indicating a link between antiviral sensing and metabolic reprogramming.
Olagnier D, Brandtoft AM, Gunderstofte C, Villadsen NL, Krapp C, Thielke AL, Laustsen A, Peri S, Hansen AL, Bonefeld L, Thyrsted J, Bruun V, Iversen MB, Lin L, Artegoitia VM, Su C, Yang L, Lin R, Balachandran S, Luo Y, Nyegaard M, Marrero B, Goldbach-Mansky R, Motwani M, Ryan DG, Fitzgerald KA, O'Neill LA, Hollensen AK, Damgaard CK, de Paoli FV, Bertram HC, Jakobsen MR, Poulsen TB, Holm CK. Olagnier D, et al. Among authors: motwani m. Nat Commun. 2018 Aug 29;9(1):3506. doi: 10.1038/s41467-018-05861-7. Nat Commun. 2018. PMID: 30158636 Free PMC article.
Genetic Models Reveal cis and trans Immune-Regulatory Activities for lincRNA-Cox2.
Elling R, Robinson EK, Shapleigh B, Liapis SC, Covarrubias S, Katzman S, Groff AF, Jiang Z, Agarwal S, Motwani M, Chan J, Sharma S, Hennessy EJ, FitzGerald GA, McManus MT, Rinn JL, Fitzgerald KA, Carpenter S. Elling R, et al. Among authors: motwani m. Cell Rep. 2018 Nov 6;25(6):1511-1524.e6. doi: 10.1016/j.celrep.2018.10.027. Cell Rep. 2018. PMID: 30404006 Free PMC article.
Hierarchy of clinical manifestations in SAVI N153S and V154M mouse models.
Motwani M, Pawaria S, Bernier J, Moses S, Henry K, Fang T, Burkly L, Marshak-Rothstein A, Fitzgerald KA. Motwani M, et al. Proc Natl Acad Sci U S A. 2019 Apr 16;116(16):7941-7950. doi: 10.1073/pnas.1818281116. Epub 2019 Apr 3. Proc Natl Acad Sci U S A. 2019. PMID: 30944222 Free PMC article.
Quantifying and mitigating motor phenotypes induced by antisense oligonucleotides in the central nervous system.
Moazami MP, Rembetsy-Brown JM, Sarli SL, McEachern HR, Wang F, Ohara M, Wagh A, Kelly K, Krishnamurthy PM, Weiss A, Marosfoi M, King RM, Motwani M, Gray-Edwards H, Fitzgerald KA, Brown RH, Watts JK. Moazami MP, et al. Among authors: motwani m. Mol Ther. 2024 Dec 4;32(12):4401-4417. doi: 10.1016/j.ymthe.2024.10.024. Epub 2024 Oct 28. Mol Ther. 2024. PMID: 39460376 Free PMC article.
213 results