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492 results

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An orthogonal methods assessment of topical drug concentrations in skin and the impact for risk assessment in the viable epidermis.
Hollingshead BD, Tomlinson L, Finley J, Doshna C, Ritenour C, Barricklow J, Oppenheimer SR, O'Neil SP, Moore JL, Patterson NH, Nicholson SP, Norris JL, Caprioli RM, Beaumont K, King-Ahmad AJ, Vispute S, Cook JC, Radi Z, Schuler M. Hollingshead BD, et al. Among authors: tomlinson l. Regul Toxicol Pharmacol. 2021 Jul;123:104934. doi: 10.1016/j.yrtph.2021.104934. Epub 2021 Apr 16. Regul Toxicol Pharmacol. 2021. PMID: 33872740
Experiments in the EpiDerm 3D Skin In Vitro Model and Minipigs In Vivo Indicate Comparatively Lower In Vivo Skin Sensitivity of Topically Applied Aneugenic Compounds.
Schuler M, Tomlinson L, Homiski M, Cheung J, Zhan Y, Coffing S, Engel M, Rubitski E, Seitis G, Hales K, Robertson A, Vispute S, Cook J, Radi Z, Hollingshead B. Schuler M, et al. Among authors: tomlinson l. Toxicol Sci. 2021 Feb 26;180(1):103-121. doi: 10.1093/toxsci/kfaa189. Toxicol Sci. 2021. PMID: 33481035
Mechanistic investigations of test article-induced pancreatic toxicity at the endocrine-exocrine interface in the rat.
Brenneman KA, Ramaiah SK, Rohde CM, Messing DM, O'Neil SP, Gauthier LM, Stewart ZS, Mantena SR, Shevlin KM, Leonard CG, Sokolowski SA, Lin H, Carraher DC, Jesson MI, Tomlinson L, Zhan Y, Bobrowski WF, Bailey SA, Vogel WM, Morris DL, Whiteley LO, Davis JW 2nd. Brenneman KA, et al. Among authors: tomlinson l. Toxicol Pathol. 2014 Jan;42(1):229-42. doi: 10.1177/0192623313508851. Epub 2013 Nov 13. Toxicol Pathol. 2014. PMID: 24226507
Perspectives on the evaluation and adoption of complex in vitro models in drug development: Workshop with the FDA and the pharmaceutical industry (IQ MPS Affiliate).
Baran SW, Brown PC, Baudy AR, Fitzpatrick SC, Frantz C, Fullerton A, Gan J, Hardwick RN, Hillgren KM, Kopec AK, Liras JL, Mendrick DL, Nagao R, Proctor WR, Ramsden D, Ribeiro AJS, Stresser D, Sung KE, Sura R, Tetsuka K, Tomlinson L, Van Vleet T, Wagoner MP, Wang Q, Arslan SY, Yoder G, Ekert JE. Baran SW, et al. Among authors: tomlinson l. ALTEX. 2022;39(2):297–314. doi: 10.14573/altex.2112203. Epub 2022 Jan 21. ALTEX. 2022. PMID: 35064273 Free article.
Scientific and Regulatory Policy Committee Points to Consider Review: Inclusion of Reproductive and Pathology End Points for Assessment of Reproductive and Developmental Toxicity in Pharmaceutical Drug Development.
Halpern WG, Ameri M, Bowman CJ, Elwell MR, Mirsky ML, Oliver J, Regan KS, Remick AK, Sutherland VL, Thompson KE, Tremblay C, Yoshida M, Tomlinson L. Halpern WG, et al. Among authors: tomlinson l. Toxicol Pathol. 2016 Aug;44(6):789-809. doi: 10.1177/0192623316650052. Epub 2016 May 27. Toxicol Pathol. 2016. PMID: 27235322 Free PMC article.
Characterizing "Adversity" of Pathology Findings in Nonclinical Toxicity Studies: Results from the 4th ESTP International Expert Workshop.
Palazzi X, Burkhardt JE, Caplain H, Dellarco V, Fant P, Foster JR, Francke S, Germann P, Gröters S, Harada T, Harleman J, Inui K, Kaufmann W, Lenz B, Nagai H, Pohlmeyer-Esch G, Schulte A, Skydsgaard M, Tomlinson L, Wood CE, Yoshida M. Palazzi X, et al. Among authors: tomlinson l. Toxicol Pathol. 2016 Aug;44(6):810-24. doi: 10.1177/0192623316642527. Epub 2016 Apr 21. Toxicol Pathol. 2016. PMID: 27102650
Toxicity of hydroxyurea in rats and dogs.
Morton D, Reed L, Huang W, Marcek JM, Austin-LaFrance R, Northcott CA, Schelling SH, Enerson BE, Tomlinson L. Morton D, et al. Among authors: tomlinson l. Toxicol Pathol. 2015 Jun;43(4):498-512. doi: 10.1177/0192623314559103. Epub 2014 Nov 11. Toxicol Pathol. 2015. PMID: 25391310
Principles for Assessing Adversity in Toxicologic Clinical Pathology.
Ramaiah L, Tomlinson L, Tripathi NK, Cregar LC, Vitsky A, Beust BV, Barlow VG, Reagan WJ, Ennulat D. Ramaiah L, et al. Among authors: tomlinson l. Toxicol Pathol. 2017 Feb;45(2):260-266. doi: 10.1177/0192623316681646. Epub 2017 Jan 5. Toxicol Pathol. 2017. PMID: 28056663 Review.
492 results