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225 results

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Page 1
Targeting altered cancer methionine metabolism with recombinant methioninase (rMETase) overcomes partial gemcitabine-resistance and regresses a patient-derived orthotopic xenograft (PDOX) nude mouse model of pancreatic cancer.
Kawaguchi K, Miyake K, Han Q, Li S, Tan Y, Igarashi K, Lwin TM, Higuchi T, Kiyuna T, Miyake M, Oshiro H, Bouvet M, Unno M, Hoffman RM. Kawaguchi K, et al. Among authors: oshiro h. Cell Cycle. 2018;17(7):868-873. doi: 10.1080/15384101.2018.1445907. Epub 2018 May 21. Cell Cycle. 2018. PMID: 29623758 Free PMC article.
Recombinant methioninase combined with doxorubicin (DOX) regresses a DOX-resistant synovial sarcoma in a patient-derived orthotopic xenograft (PDOX) mouse model.
Igarashi K, Kawaguchi K, Li S, Han Q, Tan Y, Gainor E, Kiyuna T, Miyake K, Miyake M, Higuchi T, Oshiro H, Singh AS, Eckardt MA, Nelson SD, Russell TA, Dry SM, Li Y, Yamamoto N, Hayashi K, Kimura H, Miwa S, Tsuchiya H, Eilber FC, Hoffman RM. Igarashi K, et al. Among authors: oshiro h. Oncotarget. 2018 Apr 10;9(27):19263-19272. doi: 10.18632/oncotarget.24996. eCollection 2018 Apr 10. Oncotarget. 2018. PMID: 29721200 Free PMC article.
Oral recombinant methioninase (o-rMETase) is superior to injectable rMETase and overcomes acquired gemcitabine resistance in pancreatic cancer.
Kawaguchi K, Miyake K, Han Q, Li S, Tan Y, Igarashi K, Kiyuna T, Miyake M, Higuchi T, Oshiro H, Zhang Z, Razmjooei S, Wangsiricharoen S, Bouvet M, Singh SR, Unno M, Hoffman RM. Kawaguchi K, et al. Among authors: oshiro h. Cancer Lett. 2018 Sep 28;432:251-259. doi: 10.1016/j.canlet.2018.06.016. Epub 2018 Jun 18. Cancer Lett. 2018. PMID: 29928962
Tumor-targeting Salmonella typhimurium A1-R arrests a doxorubicin-resistant PDGFRA-amplified patient-derived orthotopic xenograft mouse model of pleomorphic liposarcoma.
Kiyuna T, Tome Y, Murakami T, Zhao M, Miyake K, Igarashi K, Kawaguchi K, Miyake M, Oshiro H, Higuchi T, Li Y, Dry SM, Nelson SD, Russell TA, Eckardt MA, Singh AS, Kanaya F, Eilber FC, Hoffman RM. Kiyuna T, et al. Among authors: oshiro h. J Cell Biochem. 2018 Sep;119(9):7827-7833. doi: 10.1002/jcb.27183. Epub 2018 Jun 22. J Cell Biochem. 2018. PMID: 29932244 Free PMC article.
Tumor targeting Salmonella typhimurium A1-R in combination with gemcitabine (GEM) regresses partially GEM-resistant pancreatic cancer patient-derived orthotopic xenograft (PDOX) nude mouse models.
Kawaguchi K, Miyake K, Zhao M, Kiyuna T, Igarashi K, Miyake M, Higuchi T, Oshiro H, Bouvet M, Unno M, Hoffman RM. Kawaguchi K, et al. Among authors: oshiro h. Cell Cycle. 2018;17(16):2019-2026. doi: 10.1080/15384101.2018.1480223. Epub 2018 Sep 19. Cell Cycle. 2018. PMID: 29963961 Free PMC article.
Oral Recombinant Methioninase Combined with Caffeine and Doxorubicin Induced Regression of a Doxorubicin-resistant Synovial Sarcoma in a PDOX Mouse Model.
Higuchi T, Kawaguchi K, Miyake K, Han Q, Tan Y, Oshiro H, Sugisawa N, Zhang Z, Razmjooei S, Yamamoto N, Hayashi K, Kimura H, Miwa S, Igarashi K, Chawla SP, Singh AS, Eilber FC, Singh SR, Tsuchiya H, Hoffman RM. Higuchi T, et al. Among authors: oshiro h. Anticancer Res. 2018 Oct;38(10):5639-5644. doi: 10.21873/anticanres.12899. Anticancer Res. 2018. PMID: 30275182
A combination of irinotecan/cisplatinum and irinotecan/temozolomide or tumor-targeting Salmonella typhimurium A1-R arrest doxorubicin- and temozolomide-resistant myxofibrosarcoma in a PDOX mouse model.
Kiyuna T, Tome Y, Murakami T, Miyake K, Igarashi K, Kawaguchi K, Oshiro H, Higuchi T, Miyake M, Sugisawa N, Zhang Z, Razmjooei S, Wangsiricharoen S, Chmielowski B, Nelson SD, Russell TA, Dry SM, Li Y, Eckardt MA, Singh AS, Chawla S, Kanaya F, Eilber FC, Singh SR, Zhao M, Hoffman RM. Kiyuna T, et al. Among authors: oshiro h. Biochem Biophys Res Commun. 2018 Nov 2;505(3):733-739. doi: 10.1016/j.bbrc.2018.09.106. Epub 2018 Oct 3. Biochem Biophys Res Commun. 2018. PMID: 30292411
The combination of gemcitabine and nab-paclitaxel as a novel effective treatment strategy for undifferentiated soft-tissue sarcoma in a patient-derived orthotopic xenograft (PDOX) nude-mouse model.
Higuchi T, Kawaguchi K, Miyake K, Oshiro H, Zhang Z, Razmjooei S, Wangsiricharoen S, Igarashi K, Yamamoto N, Hayashi K, Kimura H, Miwa S, Nelson SD, Dry SM, Li Y, Chawla SP, Eilber FC, Singh SR, Tsuchiya H, Hoffman RM. Higuchi T, et al. Among authors: oshiro h. Biomed Pharmacother. 2019 Mar;111:835-840. doi: 10.1016/j.biopha.2018.12.110. Epub 2019 Jan 4. Biomed Pharmacother. 2019. PMID: 30616082 Free article.
225 results