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Discovery of 1-[2-(1-methyl-1H-pyrazol-5-yl)-[1,2,4]triazolo[1,5-a]pyridin-6-yl]-3-(pyridin-4-ylmethyl)urea as a potent NAMPT (nicotinamide phosphoribosyltransferase) activator with attenuated CYP inhibition.
Akiu M, Tsuji T, Sogawa Y, Terayama K, Yokoyama M, Tanaka J, Asano D, Sakurai K, Sergienko E, Sessions EH, Gardell SJ, Pinkerton AB, Nakamura T. Akiu M, et al. Among authors: sakurai k. Bioorg Med Chem Lett. 2021 Jul 1;43:128048. doi: 10.1016/j.bmcl.2021.128048. Epub 2021 Apr 19. Bioorg Med Chem Lett. 2021. PMID: 33887438
Datopotamab Deruxtecan, a Novel TROP2-directed Antibody-drug Conjugate, Demonstrates Potent Antitumor Activity by Efficient Drug Delivery to Tumor Cells.
Okajima D, Yasuda S, Maejima T, Karibe T, Sakurai K, Aida T, Toki T, Yamaguchi J, Kitamura M, Kamei R, Fujitani T, Honda T, Shibutani T, Muramatsu S, Nakada T, Goto R, Takahashi S, Yamaguchi M, Hamada H, Noguchi Y, Murakami M, Abe Y, Agatsuma T. Okajima D, et al. Among authors: sakurai k. Mol Cancer Ther. 2021 Dec;20(12):2329-2340. doi: 10.1158/1535-7163.MCT-21-0206. Epub 2021 Aug 19. Mol Cancer Ther. 2021. PMID: 34413126 Free PMC article.
Comprehensive analysis of cardiac function, blood biomarkers and histopathology for milrinone-induced cardiotoxicity in cynomolgus monkeys.
Chiba K, Ishizaka T, Yoshimatsu Y, Mikamoto K, Maeda Y, Iguchi T, Shirai M, Yamaguchi T, Goto K, Sakurai K, Tamai S, Kataoka H, Hasegawa M, Mori K. Chiba K, et al. Among authors: sakurai k. J Pharmacol Toxicol Methods. 2020 May-Jun;103:106870. doi: 10.1016/j.vascn.2020.106870. Epub 2020 Apr 28. J Pharmacol Toxicol Methods. 2020. PMID: 32353509
Circulating liver-specific microRNAs in cynomolgus monkeys.
Iguchi T, Sakurai K, Tamai S, Mori K. Iguchi T, et al. Among authors: sakurai k. J Toxicol Pathol. 2018 Jan;31(1):3-13. doi: 10.1293/tox.2017-0036. Epub 2017 Sep 8. J Toxicol Pathol. 2018. PMID: 29479135 Free PMC article. Review.
2,237 results