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Co-inhibition of SMAD and MAPK signaling enhances 124I uptake in BRAF-mutant thyroid cancers.
Luckett KA, Cracchiolo JR, Krishnamoorthy GP, Leandro-Garcia LJ, Nagarajah J, Saqcena M, Lester R, Im SY, Zhao Z, Lowe SW, de Stanchina E, Sherman EJ, Ho AL, Leach SD, Knauf JA, Fagin JA. Luckett KA, et al. Among authors: saqcena m. Endocr Relat Cancer. 2021 May 18;28(6):391-402. doi: 10.1530/ERC-21-0017. Endocr Relat Cancer. 2021. PMID: 33890869 Free PMC article.
Sustained ERK inhibition maximizes responses of BrafV600E thyroid cancers to radioiodine.
Nagarajah J, Le M, Knauf JA, Ferrandino G, Montero-Conde C, Pillarsetty N, Bolaender A, Irwin C, Krishnamoorthy GP, Saqcena M, Larson SM, Ho AL, Seshan V, Ishii N, Carrasco N, Rosen N, Weber WA, Fagin JA. Nagarajah J, et al. Among authors: saqcena m. J Clin Invest. 2016 Nov 1;126(11):4119-4124. doi: 10.1172/JCI89067. Epub 2016 Sep 26. J Clin Invest. 2016. PMID: 27669459 Free PMC article.
Tipifarnib Inhibits HRAS-Driven Dedifferentiated Thyroid Cancers.
Untch BR, Dos Anjos V, Garcia-Rendueles MER, Knauf JA, Krishnamoorthy GP, Saqcena M, Bhanot UK, Socci ND, Ho AL, Ghossein R, Fagin JA. Untch BR, et al. Among authors: saqcena m. Cancer Res. 2018 Aug 15;78(16):4642-4657. doi: 10.1158/0008-5472.CAN-17-1925. Epub 2018 May 14. Cancer Res. 2018. PMID: 29760048 Free PMC article.
EIF1AX and RAS Mutations Cooperate to Drive Thyroid Tumorigenesis through ATF4 and c-MYC.
Krishnamoorthy GP, Davidson NR, Leach SD, Zhao Z, Lowe SW, Lee G, Landa I, Nagarajah J, Saqcena M, Singh K, Wendel HG, Dogan S, Tamarapu PP, Blenis J, Ghossein RA, Knauf JA, Rätsch G, Fagin JA. Krishnamoorthy GP, et al. Among authors: saqcena m. Cancer Discov. 2019 Feb;9(2):264-281. doi: 10.1158/2159-8290.CD-18-0606. Epub 2018 Oct 10. Cancer Discov. 2019. PMID: 30305285 Free PMC article.
SWI/SNF Complex Mutations Promote Thyroid Tumor Progression and Insensitivity to Redifferentiation Therapies.
Saqcena M, Leandro-Garcia LJ, Maag JLV, Tchekmedyian V, Krishnamoorthy GP, Tamarapu PP, Tiedje V, Reuter V, Knauf JA, de Stanchina E, Xu B, Liao XH, Refetoff S, Ghossein R, Chi P, Ho AL, Koche RP, Fagin JA. Saqcena M, et al. Cancer Discov. 2021 May;11(5):1158-1175. doi: 10.1158/2159-8290.CD-20-0735. Epub 2020 Dec 14. Cancer Discov. 2021. PMID: 33318036 Free PMC article.
Identification of domains responsible for ubiquitin-dependent degradation of dMyc by glycogen synthase kinase 3beta and casein kinase 1 kinases.
Galletti M, Riccardo S, Parisi F, Lora C, Saqcena MK, Rivas L, Wong B, Serra A, Serras F, Grifoni D, Pelicci P, Jiang J, Bellosta P. Galletti M, et al. Among authors: saqcena mk. Mol Cell Biol. 2009 Jun;29(12):3424-34. doi: 10.1128/MCB.01535-08. Epub 2009 Apr 13. Mol Cell Biol. 2009. PMID: 19364825 Free PMC article.
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