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Double stranded RNA drives anti-viral innate immune responses, sickness behavior and cognitive dysfunction dependent on dsRNA length, IFNAR1 expression and age.
McGarry N, Murray CL, Garvey S, Wilkinson A, Tortorelli L, Ryan L, Hayden L, Healy D, Griffin EW, Hennessy E, Arumugam M, Skelly DT, Mitchell KJ, Cunningham C. McGarry N, et al. Among authors: tortorelli l. Brain Behav Immun. 2021 Jul;95:413-428. doi: 10.1016/j.bbi.2021.04.016. Epub 2021 Apr 21. Brain Behav Immun. 2021. PMID: 33892139 Free PMC article.
Acute transient cognitive dysfunction and acute brain injury induced by systemic inflammation occur by dissociable IL-1-dependent mechanisms.
Skelly DT, Griffin ÉW, Murray CL, Harney S, O'Boyle C, Hennessy E, Dansereau MA, Nazmi A, Tortorelli L, Rawlins JN, Bannerman DM, Cunningham C. Skelly DT, et al. Among authors: tortorelli l. Mol Psychiatry. 2019 Oct;24(10):1533-1548. doi: 10.1038/s41380-018-0075-8. Epub 2018 Jun 6. Mol Psychiatry. 2019. PMID: 29875474 Free PMC article.
Chronic neurodegeneration induces type I interferon synthesis via STING, shaping microglial phenotype and accelerating disease progression.
Nazmi A, Field RH, Griffin EW, Haugh O, Hennessy E, Cox D, Reis R, Tortorelli L, Murray CL, Lopez-Rodriguez AB, Jin L, Lavelle EC, Dunne A, Cunningham C. Nazmi A, et al. Among authors: tortorelli l. Glia. 2019 Jul;67(7):1254-1276. doi: 10.1002/glia.23592. Epub 2019 Jan 25. Glia. 2019. PMID: 30680794 Free PMC article.
Correction: Acute transient cognitive dysfunction and acute brain injury induced by systemic inflammation occur by dissociable IL-1-dependent mechanisms.
Skelly DT, Griffin ÉW, Murray CL, Harney S, O'Boyle C, Hennessy E, Dansereau MA, Nazmi A, Tortorelli L, Rawlins JN, Bannerman DM, Cunningham C. Skelly DT, et al. Among authors: tortorelli l. Mol Psychiatry. 2019 Oct;24(10):1566. doi: 10.1038/s41380-019-0403-7. Mol Psychiatry. 2019. PMID: 30890763 Free PMC article.
Double stranded RNA drives innate immune responses, sickness behavior and cognitive impairment dependent on dsRNA length, IFNAR1 expression and age.
McGarry N, Murray CL, Garvey S, Wilkinson A, Tortorelli L, Ryan L, Hayden L, Healy D, Griffin EW, Hennessy E, Arumugam M, Skelly DT, Mitchell KJ, Cunningham C. McGarry N, et al. Among authors: tortorelli l. bioRxiv [Preprint]. 2021 Jan 9:2021.01.09.426034. doi: 10.1101/2021.01.09.426034. bioRxiv. 2021. Update in: Brain Behav Immun. 2021 Jul;95:413-428. doi: 10.1016/j.bbi.2021.04.016 PMID: 33442686 Free PMC article. Updated. Preprint.
35 results