Chen ZD - Search Results

1

Metabolic disposition of the EGFR covalent inhibitor furmonertinib in humans.

Meng J, Zhang H, Bao JJ, Chen ZD, Liu XY, Zhang YF, Jiang Y, Miao LY, Zhong DF. Meng J, et al. Among authors: chen zd. Acta Pharmacol Sin. 2022 Feb;43(2):494-503. doi: 10.1038/s41401-021-00667-8. Epub 2021 Apr 29. Acta Pharmacol Sin. 2022. PMID: 33927359 Free PMC article.

2

Technologies to improve the sensitivity of existing chromatographic methods used for bioanalytical studies.

Chen Z, Gao Y, Zhong D. Chen Z, et al. Biomed Chromatogr. 2020 Mar;34(3):e4798. doi: 10.1002/bmc.4798. Epub 2020 Feb 9. Biomed Chromatogr. 2020. PMID: 31994210 Review.

3

Alflutinib (AST2818), primarily metabolized by CYP3A4, is a potent CYP3A4 inducer.

Liu XY, Guo ZT, Chen ZD, Zhang YF, Zhou JL, Jiang Y, Zhao QY, Diao XX, Zhong DF. Liu XY, et al. Among authors: chen zd. Acta Pharmacol Sin. 2020 Oct;41(10):1366-1376. doi: 10.1038/s41401-020-0389-3. Epub 2020 Mar 31. Acta Pharmacol Sin. 2020. PMID: 32235864 Free PMC article.

4

Furmonertinib (Alflutinib, AST2818) is a potential positive control drug comparable to rifampin for evaluation of CYP3A4 induction in sandwich-cultured primary human hepatocytes.

Wu YL, Xue YR, Guo ZT, Chen ZD, Ge XY, Zhong DF, Diao XX. Wu YL, et al. Among authors: chen zd. Acta Pharmacol Sin. 2022 Mar;43(3):747-756. doi: 10.1038/s41401-021-00692-7. Epub 2021 May 25. Acta Pharmacol Sin. 2022. PMID: 34035488 Free PMC article.

5

Effects of Food on the Pharmacokinetic Properties and Mass Balance of Henagliflozin in Healthy Male Volunteers.

Chen ZD, Chen Q, Zhu YT, Zhang YF, Zhan Y, Chen XF, Liang X, Jia JY, Yu C, Liu HY, Zou JJ, Liu YM, Zhong DF. Chen ZD, et al. Among authors: chen xf, chen q. Clin Ther. 2021 Sep;43(9):e264-e273. doi: 10.1016/j.clinthera.2021.07.008. Epub 2021 Aug 6. Clin Ther. 2021. PMID: 34366153 Clinical Trial.

6

Efficient Synthesis and Biological Evaluation of 6-Trifluoroethoxy Functionalized Pteridine Derivatives as EGFR Inhibitors.

Lin J, Zhang Z, Lin X, Chen Z, Luc T, Zha D, Wang J, Xu X, Li Z. Lin J, et al. Med Chem. 2022;18(3):353-363. doi: 10.2174/1573406417666210604105923. Med Chem. 2022. PMID: 34097593

7

Discovery of novel BTK PROTACs for B-Cell lymphomas.

Zhao Y, Shu Y, Lin J, Chen Z, Xie Q, Bao Y, Lu L, Sun N, Wang Y. Zhao Y, et al. Eur J Med Chem. 2021 Dec 5;225:113820. doi: 10.1016/j.ejmech.2021.113820. Epub 2021 Sep 2. Eur J Med Chem. 2021. PMID: 34509879

8

Discovery of novel BTK PROTACs with improved metabolic stability via linker rigidification strategy.

Chen S, Chen Z, Lu L, Zhao Y, Zhou R, Xie Q, Shu Y, Lin J, Yu X, Wang Y. Chen S, et al. Eur J Med Chem. 2023 Jul 5;255:115403. doi: 10.1016/j.ejmech.2023.115403. Epub 2023 Apr 20. Eur J Med Chem. 2023. PMID: 37119666

9

The expansion and loss of specific olfactory genes in relatives of parasitic lice, the stored-product psocids (Psocodea: Liposcelididae).

Sun J, Wu J, Sun SY, Chen ZD, Smagghe G, Wang JJ, Wei DD. Sun J, et al. Among authors: chen zd. BMC Genomics. 2025 Jan 15;26(1):41. doi: 10.1186/s12864-025-11231-7. BMC Genomics. 2025. PMID: 39815200 Free PMC article.

10

Activation of TFEB protects against diabetic vascular calcification by improving autophagic flux and activating Nrf2 antioxidant system.

Sun XJ, Xiao SJ, Ma WQ, Jin H, Ren LQ, Yao YY, Chen ZD, Li XX, Chen T, Liu NF. Sun XJ, et al. Among authors: chen zd. Am J Physiol Endocrinol Metab. 2025 Jan 13. doi: 10.1152/ajpendo.00161.2023. Online ahead of print. Am J Physiol Endocrinol Metab. 2025. PMID: 39805031

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