Ha DP - Search Results

1

Endoplasmic reticulum chaperone GRP78/BiP is critical for mutant Kras-driven lung tumorigenesis.

Rangel DF, Dubeau L, Park R, Chan P, Ha DP, Pulido MA, Mullen DJ, Vorobyova I, Zhou B, Borok Z, Offringa IA, Lee AS. Rangel DF, et al. Among authors: ha dp. Oncogene. 2021 May;40(20):3624-3632. doi: 10.1038/s41388-021-01791-9. Epub 2021 Apr 30. Oncogene. 2021. PMID: 33931739 Free PMC article.

2

Targeted deletion of ER chaperone GRP94 in the liver results in injury, repopulation of GRP94-positive hepatocytes, and spontaneous hepatocellular carcinoma development in aged mice.

Chen WT, Ha D, Kanel G, Lee AS. Chen WT, et al. Neoplasia. 2014 Aug;16(8):617-26. doi: 10.1016/j.neo.2014.07.005. Neoplasia. 2014. PMID: 25220589 Free PMC article.

3

GRP78 haploinsufficiency suppresses acinar-to-ductal metaplasia, signaling, and mutant Kras-driven pancreatic tumorigenesis in mice.

Shen J, Ha DP, Zhu G, Rangel DF, Kobielak A, Gill PS, Groshen S, Dubeau L, Lee AS. Shen J, et al. Among authors: ha dp. Proc Natl Acad Sci U S A. 2017 May 16;114(20):E4020-E4029. doi: 10.1073/pnas.1616060114. Epub 2017 May 1. Proc Natl Acad Sci U S A. 2017. PMID: 28461470 Free PMC article.

4

New role of endoplasmic reticulum chaperones in regulating metaplasia during tumorigenesis.

Shen J, Rangel DF, Ha D, Lee AS. Shen J, et al. Mol Cell Oncol. 2017 Jun 30;4(6):e1345350. doi: 10.1080/23723556.2017.1345350. eCollection 2017. Mol Cell Oncol. 2017. PMID: 29209644 Free PMC article.

5

Endoplasmic reticulum stress activates SRC, relocating chaperones to the cell surface where GRP78/CD109 blocks TGF-β signaling.

Tsai YL, Ha DP, Zhao H, Carlos AJ, Wei S, Pun TK, Wu K, Zandi E, Kelly K, Lee AS. Tsai YL, et al. Among authors: ha dp. Proc Natl Acad Sci U S A. 2018 May 1;115(18):E4245-E4254. doi: 10.1073/pnas.1714866115. Epub 2018 Apr 13. Proc Natl Acad Sci U S A. 2018. PMID: 29654145 Free PMC article.

6

Suppression of stress induction of the 78-kilodalton glucose regulated protein (GRP78) in cancer by IT-139, an anti-tumor ruthenium small molecule inhibitor.

Bakewell SJ, Rangel DF, Ha DP, Sethuraman J, Crouse R, Hadley E, Costich TL, Zhou X, Nichols P, Lee AS. Bakewell SJ, et al. Among authors: ha dp. Oncotarget. 2018 Jul 3;9(51):29698-29714. doi: 10.18632/oncotarget.25679. eCollection 2018 Jul 3. Oncotarget. 2018. PMID: 30038714 Free PMC article.

7

The stress-inducible molecular chaperone GRP78 as potential therapeutic target for coronavirus infection.

Ha DP, Van Krieken R, Carlos AJ, Lee AS. Ha DP, et al. J Infect. 2020 Sep;81(3):452-482. doi: 10.1016/j.jinf.2020.06.017. Epub 2020 Jun 12. J Infect. 2020. PMID: 32535155 Free PMC article. No abstract available.

8

Insulin-like growth factor 1-receptor signaling stimulates GRP78 expression through the PI3K/AKT/mTOR/ATF4 axis.

Ha DP, Lee AS. Ha DP, et al. Cell Signal. 2020 Nov;75:109736. doi: 10.1016/j.cellsig.2020.109736. Epub 2020 Aug 14. Cell Signal. 2020. PMID: 32805346 Free PMC article.

9

The chaperone GRP78 is a host auxiliary factor for SARS-CoV-2 and GRP78 depleting antibody blocks viral entry and infection.

Carlos AJ, Ha DP, Yeh DW, Van Krieken R, Tseng CC, Zhang P, Gill P, Machida K, Lee AS. Carlos AJ, et al. Among authors: ha dp. J Biol Chem. 2021 Jan-Jun;296:100759. doi: 10.1016/j.jbc.2021.100759. Epub 2021 May 7. J Biol Chem. 2021. PMID: 33965375 Free PMC article.

10

ER residential chaperone GRP78 unconventionally relocalizes to the cell surface via endosomal transport.

Van Krieken R, Tsai YL, Carlos AJ, Ha DP, Lee AS. Van Krieken R, et al. Among authors: ha dp. Cell Mol Life Sci. 2021 Jun;78(12):5179-5195. doi: 10.1007/s00018-021-03849-z. Epub 2021 May 11. Cell Mol Life Sci. 2021. PMID: 33974094 Free PMC article.

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