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The ZEB2-dependent EMT transcriptional programme drives therapy resistance by activating nucleotide excision repair genes ERCC1 and ERCC4 in colorectal cancer.
Sreekumar R, Al-Saihati H, Emaduddin M, Moutasim K, Mellone M, Patel A, Kilic S, Cetin M, Erdemir S, Navio MS, Lopez MA, Curtis N, Yagci T, Primrose JN, Price BD, Berx G, Thomas GJ, Tulchinsky E, Mirnezami A, Sayan AE. Sreekumar R, et al. Among authors: berx g. Mol Oncol. 2021 Aug;15(8):2065-2083. doi: 10.1002/1878-0261.12965. Epub 2021 May 1. Mol Oncol. 2021. PMID: 33931939 Free PMC article.
The EMT regulator Zeb2/Sip1 is essential for murine embryonic hematopoietic stem/progenitor cell differentiation and mobilization.
Goossens S, Janzen V, Bartunkova S, Yokomizo T, Drogat B, Crisan M, Haigh K, Seuntjens E, Umans L, Riedt T, Bogaert P, Haenebalcke L, Berx G, Dzierzak E, Huylebroeck D, Haigh JJ. Goossens S, et al. Among authors: berx g. Blood. 2011 May 26;117(21):5620-30. doi: 10.1182/blood-2010-08-300236. Epub 2011 Feb 25. Blood. 2011. PMID: 21355089 Free article.
ZEB2-transgene expression in the epidermis compromises the integrity of the epidermal barrier through the repression of different tight junction proteins.
Tatari MN, De Craene B, Soen B, Taminau J, Vermassen P, Goossens S, Haigh K, Cazzola S, Lambert J, Huylebroeck D, Haigh JJ, Berx G. Tatari MN, et al. Among authors: berx g. Cell Mol Life Sci. 2014 Sep;71(18):3599-609. doi: 10.1007/s00018-014-1589-0. Epub 2014 Feb 27. Cell Mol Life Sci. 2014. PMID: 24573695 Free PMC article.
ZEB2 in T-cells and T-ALL.
De Coninck S, Berx G, Taghon T, Van Vlierberghe P, Goossens S. De Coninck S, et al. Among authors: berx g. Adv Biol Regul. 2019 Dec;74:100639. doi: 10.1016/j.jbior.2019.100639. Epub 2019 Jul 27. Adv Biol Regul. 2019. PMID: 31383581 Review.
The EMT Transcription Factor ZEB2 Promotes Proliferation of Primary and Metastatic Melanoma While Suppressing an Invasive, Mesenchymal-Like Phenotype.
Vandamme N, Denecker G, Bruneel K, Blancke G, Akay Ö, Taminau J, De Coninck J, De Smedt E, Skrypek N, Van Loocke W, Wouters J, Nittner D, Köhler C, Darling DS, Cheng PF, Raaijmakers MIG, Levesque MP, Mallya UG, Rafferty M, Balint B, Gallagher WM, Brochez L, Huylebroeck D, Haigh JJ, Andries V, Rambow F, Van Vlierberghe P, Goossens S, van den Oord JJ, Marine JC, Berx G. Vandamme N, et al. Among authors: berx g. Cancer Res. 2020 Jul 15;80(14):2983-2995. doi: 10.1158/0008-5472.CAN-19-2373. Epub 2020 Jun 5. Cancer Res. 2020. PMID: 32503808
147 results