Coyne AG - Search Results

1

Targeting Mycobacterium tuberculosis CoaBC through Chemical Inhibition of 4'-Phosphopantothenoyl-l-cysteine Synthetase (CoaB) Activity.

Evans JC, Murugesan D, Post JM, Mendes V, Wang Z, Nahiyaan N, Lynch SL, Thompson S, Green SR, Ray PC, Hess J, Spry C, Coyne AG, Abell C, Boshoff HIM, Wyatt PG, Rhee KY, Blundell TL, Barry CE 3rd, Mizrahi V. Evans JC, et al. Among authors: coyne ag. ACS Infect Dis. 2021 Jun 11;7(6):1666-1679. doi: 10.1021/acsinfecdis.0c00904. Epub 2021 May 3. ACS Infect Dis. 2021. PMID: 33939919 Free PMC article.

2

Drugging challenging targets using fragment-based approaches.

Coyne AG, Scott DE, Abell C. Coyne AG, et al. Curr Opin Chem Biol. 2010 Jun;14(3):299-307. doi: 10.1016/j.cbpa.2010.02.010. Epub 2010 Mar 10. Curr Opin Chem Biol. 2010. PMID: 20223699 Review.

3

Fragment-based approaches in drug discovery and chemical biology.

Scott DE, Coyne AG, Hudson SA, Abell C. Scott DE, et al. Among authors: coyne ag. Biochemistry. 2012 Jun 26;51(25):4990-5003. doi: 10.1021/bi3005126. Epub 2012 Jun 14. Biochemistry. 2012. PMID: 22697260 Review.

4

Overcoming the limitations of fragment merging: rescuing a strained merged fragment series targeting Mycobacterium tuberculosis CYP121.

Hudson SA, Surade S, Coyne AG, McLean KJ, Leys D, Munro AW, Abell C. Hudson SA, et al. Among authors: coyne ag. ChemMedChem. 2013 Sep;8(9):1451-6. doi: 10.1002/cmdc.201300219. Epub 2013 Jun 20. ChemMedChem. 2013. PMID: 23788280 Free PMC article.

5

Regioselective conversion of arenes to N-aryl-1,2,3-triazoles using C-H borylation.

Srinivasan R, Coyne AG, Abell C. Srinivasan R, et al. Among authors: coyne ag. Chemistry. 2014 Sep 8;20(37):11680-4. doi: 10.1002/chem.201403021. Epub 2014 Jul 22. Chemistry. 2014. PMID: 25048717

6

Small-molecule inhibitors that target protein-protein interactions in the RAD51 family of recombinases.

Scott DE, Coyne AG, Venkitaraman A, Blundell TL, Abell C, Hyvönen M. Scott DE, et al. Among authors: coyne ag. ChemMedChem. 2015 Feb;10(2):296-303. doi: 10.1002/cmdc.201402428. Epub 2014 Dec 2. ChemMedChem. 2015. PMID: 25470112 Free PMC article.

7

Fragment-Based Approaches to the Development of Mycobacterium tuberculosis CYP121 Inhibitors.

Kavanagh ME, Coyne AG, McLean KJ, James GG, Levy CW, Marino LB, de Carvalho LP, Chan DS, Hudson SA, Surade S, Leys D, Munro AW, Abell C. Kavanagh ME, et al. Among authors: coyne ag. J Med Chem. 2016 Apr 14;59(7):3272-302. doi: 10.1021/acs.jmedchem.6b00007. Epub 2016 Mar 22. J Med Chem. 2016. PMID: 27002486 Free PMC article.

8

Spirooxindoles as novel 3D-fragment scaffolds: Synthesis and screening against CYP121 from M. tuberculosis.

Davis HJ, Kavanagh ME, Balan T, Abell C, Coyne AG. Davis HJ, et al. Among authors: coyne ag. Bioorg Med Chem Lett. 2016 Aug 1;26(15):3735-40. doi: 10.1016/j.bmcl.2016.05.073. Epub 2016 May 26. Bioorg Med Chem Lett. 2016. PMID: 27287372

9

Substrate Fragmentation for the Design of M. tuberculosis CYP121 Inhibitors.

Kavanagh ME, Gray JL, Gilbert SH, Coyne AG, McLean KJ, Davis HJ, Munro AW, Abell C. Kavanagh ME, et al. Among authors: coyne ag. ChemMedChem. 2016 Sep 6;11(17):1924-35. doi: 10.1002/cmdc.201600248. Epub 2016 Jul 19. ChemMedChem. 2016. PMID: 27432475 Free PMC article.

10

Fragment-based approaches to TB drugs.

Marchetti C, Chan DSH, Coyne AG, Abell C. Marchetti C, et al. Among authors: coyne ag. Parasitology. 2018 Feb;145(2):184-195. doi: 10.1017/S0031182016001876. Epub 2016 Nov 2. Parasitology. 2018. PMID: 27804891 Review.

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