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Targeting Mycobacterium tuberculosis CoaBC through Chemical Inhibition of 4'-Phosphopantothenoyl-l-cysteine Synthetase (CoaB) Activity.
Evans JC, Murugesan D, Post JM, Mendes V, Wang Z, Nahiyaan N, Lynch SL, Thompson S, Green SR, Ray PC, Hess J, Spry C, Coyne AG, Abell C, Boshoff HIM, Wyatt PG, Rhee KY, Blundell TL, Barry CE 3rd, Mizrahi V. Evans JC, et al. Among authors: hess j. ACS Infect Dis. 2021 Jun 11;7(6):1666-1679. doi: 10.1021/acsinfecdis.0c00904. Epub 2021 May 3. ACS Infect Dis. 2021. PMID: 33939919 Free PMC article.
Inhibiting Mycobacterium tuberculosis CoaBC by targeting an allosteric site.
Mendes V, Green SR, Evans JC, Hess J, Blaszczyk M, Spry C, Bryant O, Cory-Wright J, Chan DS, Torres PHM, Wang Z, Nahiyaan N, O'Neill S, Damerow S, Post J, Bayliss T, Lynch SL, Coyne AG, Ray PC, Abell C, Rhee KY, Boshoff HIM, Barry CE 3rd, Mizrahi V, Wyatt PG, Blundell TL. Mendes V, et al. Among authors: hess j. Nat Commun. 2021 Jan 8;12(1):143. doi: 10.1038/s41467-020-20224-x. Nat Commun. 2021. PMID: 33420031 Free PMC article.
Discovery of Novel Inhibitors of Uridine Diphosphate-N-Acetylenolpyruvylglucosamine Reductase (MurB) from Pseudomonas aeruginosa, an Opportunistic Infectious Agent Causing Death in Cystic Fibrosis Patients.
Acebrón-García-de-Eulate M, Mayol-Llinàs J, Holland MTO, Kim SY, Brown KP, Marchetti C, Hess J, Di Pietro O, Mendes V, Abell C, Floto RA, Coyne AG, Blundell TL. Acebrón-García-de-Eulate M, et al. Among authors: hess j. J Med Chem. 2022 Feb 10;65(3):2149-2173. doi: 10.1021/acs.jmedchem.1c01684. Epub 2022 Jan 26. J Med Chem. 2022. PMID: 35080396 Free PMC article.
Meta-Analysis of Transcriptomic Studies of Blood and Six Brain Regions Identifies a Consensus of 15 Cross-Tissue Mechanisms in Alzheimer's Disease and Suggests an Origin of Cross-Study Heterogeneity.
Hou J, Hess JL, Zhang C, van Rooij JGJ, Hearn GC, Fan CC, Faraone SV, Fennema-Notestine C, Lin SJ, Escott-Price V, Seshadri S; Alzheimer's Disease Neuroimaging Initiative; Holmans P, Tsuang MT, Kremen WS, Gaiteri C, Glatt SJ. Hou J, et al. Among authors: hess jl. Am J Med Genet B Neuropsychiatr Genet. 2024 Dec 16:e33019. doi: 10.1002/ajmg.b.33019. Online ahead of print. Am J Med Genet B Neuropsychiatr Genet. 2024. PMID: 39679839
2,221 results