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Targeting Mycobacterium tuberculosis CoaBC through Chemical Inhibition of 4'-Phosphopantothenoyl-l-cysteine Synthetase (CoaB) Activity.
Evans JC, Murugesan D, Post JM, Mendes V, Wang Z, Nahiyaan N, Lynch SL, Thompson S, Green SR, Ray PC, Hess J, Spry C, Coyne AG, Abell C, Boshoff HIM, Wyatt PG, Rhee KY, Blundell TL, Barry CE 3rd, Mizrahi V. Evans JC, et al. Among authors: spry c. ACS Infect Dis. 2021 Jun 11;7(6):1666-1679. doi: 10.1021/acsinfecdis.0c00904. Epub 2021 May 3. ACS Infect Dis. 2021. PMID: 33939919 Free PMC article.
Inhibiting Mycobacterium tuberculosis CoaBC by targeting an allosteric site.
Mendes V, Green SR, Evans JC, Hess J, Blaszczyk M, Spry C, Bryant O, Cory-Wright J, Chan DS, Torres PHM, Wang Z, Nahiyaan N, O'Neill S, Damerow S, Post J, Bayliss T, Lynch SL, Coyne AG, Ray PC, Abell C, Rhee KY, Boshoff HIM, Barry CE 3rd, Mizrahi V, Wyatt PG, Blundell TL. Mendes V, et al. Among authors: spry c. Nat Commun. 2021 Jan 8;12(1):143. doi: 10.1038/s41467-020-20224-x. Nat Commun. 2021. PMID: 33420031 Free PMC article.
Chemical Validation of Mycobacterium tuberculosis Phosphopantetheine Adenylyltransferase Using Fragment Linking and CRISPR Interference.
El Bakali J, Blaszczyk M, Evans JC, Boland JA, McCarthy WJ, Fathoni I, Dias MVB, Johnson EO, Coyne AG, Mizrahi V, Blundell TL, Abell C, Spry C. El Bakali J, et al. Among authors: spry c. Angew Chem Int Ed Engl. 2023 Apr 17;62(17):e202300221. doi: 10.1002/anie.202300221. Epub 2023 Mar 13. Angew Chem Int Ed Engl. 2023. PMID: 36757665 Free PMC article.
Pantothenate biosynthesis in Toxoplasma gondii tachyzoites is not a drug target.
Howieson VM, Zeng J, Kloehn J, Spry C, Marchetti C, Lunghi M, Varesio E, Soper A, Coyne AG, Abell C, van Dooren GG, Saliba KJ. Howieson VM, et al. Among authors: spry c. Int J Parasitol Drugs Drug Resist. 2023 Aug;22:1-8. doi: 10.1016/j.ijpddr.2023.03.003. Epub 2023 Mar 15. Int J Parasitol Drugs Drug Resist. 2023. PMID: 37004488 Free PMC article.
Chemical Validation of Mycobacterium tuberculosis Phosphopantetheine Adenylyltransferase Using Fragment Linking and CRISPR Interference.
El Bakali J, Blaszczyk M, Evans JC, Boland JA, McCarthy WJ, Fathoni I, Dias MVB, Johnson EO, Coyne AG, Mizrahi V, Blundell TL, Abell C, Spry C. El Bakali J, et al. Among authors: spry c. Angew Chem Weinheim Bergstr Ger. 2023 Apr 17;135(17):e202300221. doi: 10.1002/ange.202300221. Epub 2023 Mar 13. Angew Chem Weinheim Bergstr Ger. 2023. PMID: 38515507 Free PMC article.
Coenzyme A biosynthesis: an antimicrobial drug target.
Spry C, Kirk K, Saliba KJ. Spry C, et al. FEMS Microbiol Rev. 2008 Jan;32(1):56-106. doi: 10.1111/j.1574-6976.2007.00093.x. FEMS Microbiol Rev. 2008. PMID: 18173393 Free article. Review.
206 results