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The C-terminal PHDVC5HCH tandem domain of NSD2 is a combinatorial reader of unmodified H3K4 and tri-methylated H3K27 that regulates transcription of cell adhesion genes in multiple myeloma.
Berardi A, Kaestner CL, Ghitti M, Quilici G, Cocomazzi P, Li J, Ballabio F, Zucchelli C, Knapp S, Licht JD, Musco G. Berardi A, et al. Among authors: kaestner cl. Nucleic Acids Res. 2025 Jan 7;53(1):gkae1121. doi: 10.1093/nar/gkae1121. Nucleic Acids Res. 2025. PMID: 39656918 Free PMC article.
Targeting epigenetic mechanisms to overcome venetoclax resistance.
Prado G, Kaestner CL, Licht JD, Bennett RL. Prado G, et al. Among authors: kaestner cl. Biochim Biophys Acta Mol Cell Res. 2021 Jul;1868(8):119047. doi: 10.1016/j.bbamcr.2021.119047. Epub 2021 May 1. Biochim Biophys Acta Mol Cell Res. 2021. PMID: 33945824 Free PMC article. Review.