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Unanchored K48-linked polyubiquitin synthesized by the E3-ubiquitin ligase TRIM6 stimulates the interferon-IKKε kinase-mediated antiviral response.
Rajsbaum R, Versteeg GA, Schmid S, Maestre AM, Belicha-Villanueva A, Martínez-Romero C, Patel JR, Morrison J, Pisanelli G, Miorin L, Laurent-Rolle M, Moulton HM, Stein DA, Fernandez-Sesma A, tenOever BR, García-Sastre A. Rajsbaum R, et al. Immunity. 2014 Jun 19;40(6):880-95. doi: 10.1016/j.immuni.2014.04.018. Epub 2014 May 29. Immunity. 2014. PMID: 24882218 Free PMC article.
A Potent Anti-influenza Compound Blocks Fusion through Stabilization of the Prefusion Conformation of the Hemagglutinin Protein.
White KM, De Jesus P, Chen Z, Abreu P Jr, Barile E, Mak PA, Anderson P, Nguyen QT, Inoue A, Stertz S, Koenig R, Pellecchia M, Palese P, Kuhen K, García-Sastre A, Chanda SK, Shaw ML. White KM, et al. ACS Infect Dis. 2015 Feb 13;1(2):98-109. doi: 10.1021/id500022h. Epub 2014 Dec 15. ACS Infect Dis. 2015. PMID: 25984567 Free PMC article.
Zika Virus Targets Human STAT2 to Inhibit Type I Interferon Signaling.
Grant A, Ponia SS, Tripathi S, Balasubramaniam V, Miorin L, Sourisseau M, Schwarz MC, Sánchez-Seco MP, Evans MJ, Best SM, García-Sastre A. Grant A, et al. Cell Host Microbe. 2016 Jun 8;19(6):882-90. doi: 10.1016/j.chom.2016.05.009. Epub 2016 May 19. Cell Host Microbe. 2016. PMID: 27212660 Free PMC article.
Structures of NS5 Methyltransferase from Zika Virus.
Coloma J, Jain R, Rajashankar KR, García-Sastre A, Aggarwal AK. Coloma J, et al. Cell Rep. 2016 Sep 20;16(12):3097-3102. doi: 10.1016/j.celrep.2016.08.091. Epub 2016 Sep 12. Cell Rep. 2016. PMID: 27633330 Free PMC article.
Antagonism of type I interferon by flaviviruses.
Miorin L, Maestre AM, Fernandez-Sesma A, García-Sastre A. Miorin L, et al. Biochem Biophys Res Commun. 2017 Oct 28;492(4):587-596. doi: 10.1016/j.bbrc.2017.05.146. Epub 2017 May 31. Biochem Biophys Res Commun. 2017. PMID: 28576494 Free PMC article. Review.
821 results