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Cryo-EM structure of the DNA-PK holoenzyme.
Sharif H, Li Y, Dong Y, Dong L, Wang WL, Mao Y, Wu H. Sharif H, et al. Among authors: wu h. Proc Natl Acad Sci U S A. 2017 Jul 11;114(28):7367-7372. doi: 10.1073/pnas.1707386114. Epub 2017 Jun 26. Proc Natl Acad Sci U S A. 2017. PMID: 28652322 Free PMC article.
Molecular mechanism for NLRP6 inflammasome assembly and activation.
Shen C, Lu A, Xie WJ, Ruan J, Negro R, Egelman EH, Fu TM, Wu H. Shen C, et al. Among authors: wu h. Proc Natl Acad Sci U S A. 2019 Feb 5;116(6):2052-2057. doi: 10.1073/pnas.1817221116. Epub 2019 Jan 23. Proc Natl Acad Sci U S A. 2019. PMID: 30674671 Free PMC article.
Structural mechanism for NEK7-licensed activation of NLRP3 inflammasome.
Sharif H, Wang L, Wang WL, Magupalli VG, Andreeva L, Qiao Q, Hauenstein AV, Wu Z, Núñez G, Mao Y, Wu H. Sharif H, et al. Among authors: wu h, wu z. Nature. 2019 Jun;570(7761):338-343. doi: 10.1038/s41586-019-1295-z. Epub 2019 Jun 12. Nature. 2019. PMID: 31189953 Free PMC article.
Keeping the Death Protein in Check.
Wang L, Wu H. Wang L, et al. Among authors: wu h. Immunity. 2019 Jul 16;51(1):1-2. doi: 10.1016/j.immuni.2019.06.011. Immunity. 2019. PMID: 31315028 Free PMC article.
Mechanism and Regulation of Gasdermin-Mediated Cell Death.
Xia S, Hollingsworth LR 4th, Wu H. Xia S, et al. Among authors: wu h. Cold Spring Harb Perspect Biol. 2020 Mar 2;12(3):a036400. doi: 10.1101/cshperspect.a036400. Cold Spring Harb Perspect Biol. 2020. PMID: 31451512 Free PMC article. Review.
FDA-approved disulfiram inhibits pyroptosis by blocking gasdermin D pore formation.
Hu JJ, Liu X, Xia S, Zhang Z, Zhang Y, Zhao J, Ruan J, Luo X, Lou X, Bai Y, Wang J, Hollingsworth LR, Magupalli VG, Zhao L, Luo HR, Kim J, Lieberman J, Wu H. Hu JJ, et al. Among authors: wu h. Nat Immunol. 2020 Jul;21(7):736-745. doi: 10.1038/s41590-020-0669-6. Epub 2020 May 4. Nat Immunol. 2020. PMID: 32367036 Free PMC article.
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