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Sulfide catabolism ameliorates hypoxic brain injury.
Marutani E, Morita M, Hirai S, Kai S, Grange RMH, Miyazaki Y, Nagashima F, Traeger L, Magliocca A, Ida T, Matsunaga T, Flicker DR, Corman B, Mori N, Yamazaki Y, Batten A, Li R, Tanaka T, Ikeda T, Nakagawa A, Atochin DN, Ihara H, Olenchock BA, Shen X, Nishida M, Hanaoka K, Kevil CG, Xian M, Bloch DB, Akaike T, Hindle AG, Motohashi H, Ichinose F. Marutani E, et al. Among authors: tanaka t. Nat Commun. 2021 May 25;12(1):3108. doi: 10.1038/s41467-021-23363-x. Nat Commun. 2021. PMID: 34035265 Free PMC article.
TRPC5-eNOS Axis Negatively Regulates ATP-Induced Cardiomyocyte Hypertrophy.
Sunggip C, Shimoda K, Oda S, Tanaka T, Nishiyama K, Mangmool S, Nishimura A, Numaga-Tomita T, Nishida M. Sunggip C, et al. Among authors: tanaka t. Front Pharmacol. 2018 May 22;9:523. doi: 10.3389/fphar.2018.00523. eCollection 2018. Front Pharmacol. 2018. PMID: 29872396 Free PMC article.
TRPC channels in exercise-mimetic therapy.
Numaga-Tomita T, Oda S, Nishiyama K, Tanaka T, Nishimura A, Nishida M. Numaga-Tomita T, et al. Among authors: tanaka t. Pflugers Arch. 2019 Mar;471(3):507-517. doi: 10.1007/s00424-018-2211-3. Epub 2018 Oct 8. Pflugers Arch. 2019. PMID: 30298191 Free PMC article. Review.
Hypoxia-induced interaction of filamin with Drp1 causes mitochondrial hyperfission-associated myocardial senescence.
Nishimura A, Shimauchi T, Tanaka T, Shimoda K, Toyama T, Kitajima N, Ishikawa T, Shindo N, Numaga-Tomita T, Yasuda S, Sato Y, Kuwahara K, Kumagai Y, Akaike T, Ide T, Ojida A, Mori Y, Nishida M. Nishimura A, et al. Among authors: tanaka t. Sci Signal. 2018 Nov 13;11(556):eaat5185. doi: 10.1126/scisignal.aat5185. Sci Signal. 2018. PMID: 30425165
Mitochondrial dynamics in exercise physiology.
Tanaka T, Nishimura A, Nishiyama K, Goto T, Numaga-Tomita T, Nishida M. Tanaka T, et al. Pflugers Arch. 2020 Feb;472(2):137-153. doi: 10.1007/s00424-019-02258-3. Epub 2019 Feb 1. Pflugers Arch. 2020. PMID: 30707289 Review.
TRPC6 regulates phenotypic switching of vascular smooth muscle cells through plasma membrane potential-dependent coupling with PTEN.
Numaga-Tomita T, Shimauchi T, Oda S, Tanaka T, Nishiyama K, Nishimura A, Birnbaumer L, Mori Y, Nishida M. Numaga-Tomita T, et al. Among authors: tanaka t. FASEB J. 2019 Sep;33(9):9785-9796. doi: 10.1096/fj.201802811R. Epub 2019 Jun 4. FASEB J. 2019. PMID: 31162976 Free PMC article.
Given the marked up-regulation of TRPC6 observed in vascular disorders, our findings suggest that attenuation of TRPC6 channel activity in pathologic VSMCs could be a rational strategy to maintain vascular quality control by fine-tuning of VSMC phenotypic switching.-Numaga-Tomita …
Given the marked up-regulation of TRPC6 observed in vascular disorders, our findings suggest that attenuation of TRPC6 channel activity in p …
Ibudilast attenuates doxorubicin-induced cytotoxicity by suppressing formation of TRPC3 channel and NADPH oxidase 2 protein complexes.
Nishiyama K, Numaga-Tomita T, Fujimoto Y, Tanaka T, Toyama C, Nishimura A, Yamashita T, Matsunaga N, Koyanagi S, Azuma YT, Ibuki Y, Uchida K, Ohdo S, Nishida M. Nishiyama K, et al. Among authors: tanaka t. Br J Pharmacol. 2019 Sep;176(18):3723-3738. doi: 10.1111/bph.14777. Epub 2019 Aug 6. Br J Pharmacol. 2019. PMID: 31241172 Free PMC article.
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