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Bromodomain protein BRD4 directs and sustains CD8 T cell differentiation during infection.
Milner JJ, Toma C, Quon S, Omilusik K, Scharping NE, Dey A, Reina-Campos M, Nguyen H, Getzler AJ, Diao H, Yu B, Delpoux A, Yoshida TM, Li D, Qi J, Vincek A, Hedrick SM, Egawa T, Zhou MM, Crotty S, Ozato K, Pipkin ME, Goldrath AW. Milner JJ, et al. Among authors: crotty s. J Exp Med. 2021 Aug 2;218(8):e20202512. doi: 10.1084/jem.20202512. Epub 2021 May 26. J Exp Med. 2021. PMID: 34037670 Free PMC article.
STAT5 is a potent negative regulator of TFH cell differentiation.
Johnston RJ, Choi YS, Diamond JA, Yang JA, Crotty S. Johnston RJ, et al. Among authors: crotty s. J Exp Med. 2012 Feb 13;209(2):243-50. doi: 10.1084/jem.20111174. Epub 2012 Jan 23. J Exp Med. 2012. PMID: 22271576 Free PMC article.
Exogenous OX40 stimulation during lymphocytic choriomeningitis virus infection impairs follicular Th cell differentiation and diverts CD4 T cells into the effector lineage by upregulating Blimp-1.
Boettler T, Choi YS, Salek-Ardakani S, Cheng Y, Moeckel F, Croft M, Crotty S, von Herrath M. Boettler T, et al. Among authors: crotty s. J Immunol. 2013 Nov 15;191(10):5026-35. doi: 10.4049/jimmunol.1300013. Epub 2013 Oct 7. J Immunol. 2013. PMID: 24101548 Free PMC article.
The transcription factor NFAT promotes exhaustion of activated CD8⁺ T cells.
Martinez GJ, Pereira RM, Äijö T, Kim EY, Marangoni F, Pipkin ME, Togher S, Heissmeyer V, Zhang YC, Crotty S, Lamperti ED, Ansel KM, Mempel TR, Lähdesmäki H, Hogan PG, Rao A. Martinez GJ, et al. Among authors: crotty s. Immunity. 2015 Feb 17;42(2):265-278. doi: 10.1016/j.immuni.2015.01.006. Epub 2015 Feb 10. Immunity. 2015. PMID: 25680272 Free PMC article.
340 results