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Findings from recent studies by the Japan Aerospace Exploration Agency examining musculoskeletal atrophy in space and on Earth.
Furukawa S, Chatani M, Higashitani A, Higashibata A, Kawano F, Nikawa T, Numaga-Tomita T, Ogura T, Sato F, Sehara-Fujisawa A, Shinohara M, Shimazu T, Takahashi S, Watanabe-Takano H. Furukawa S, et al. Among authors: nikawa t. NPJ Microgravity. 2021 May 26;7(1):18. doi: 10.1038/s41526-021-00145-9. NPJ Microgravity. 2021. PMID: 34039989 Free PMC article. Review.
Ubiquitin ligase Cbl-b is a negative regulator for insulin-like growth factor 1 signaling during muscle atrophy caused by unloading.
Nakao R, Hirasaka K, Goto J, Ishidoh K, Yamada C, Ohno A, Okumura Y, Nonaka I, Yasutomo K, Baldwin KM, Kominami E, Higashibata A, Nagano K, Tanaka K, Yasui N, Mills EM, Takeda S, Nikawa T. Nakao R, et al. Among authors: nikawa t. Mol Cell Biol. 2009 Sep;29(17):4798-811. doi: 10.1128/MCB.01347-08. Epub 2009 Jun 22. Mol Cell Biol. 2009. PMID: 19546233 Free PMC article.
Reactive oxygen species upregulate expression of muscle atrophy-associated ubiquitin ligase Cbl-b in rat L6 skeletal muscle cells.
Uchida T, Sakashita Y, Kitahata K, Yamashita Y, Tomida C, Kimori Y, Komatsu A, Hirasaka K, Ohno A, Nakao R, Higashitani A, Higashibata A, Ishioka N, Shimazu T, Kobayashi T, Okumura Y, Choi I, Oarada M, Mills EM, Teshima-Kondo S, Takeda S, Tanaka E, Tanaka K, Sokabe M, Nikawa T. Uchida T, et al. Among authors: nikawa t. Am J Physiol Cell Physiol. 2018 Jun 1;314(6):C721-C731. doi: 10.1152/ajpcell.00184.2017. Epub 2018 Mar 7. Am J Physiol Cell Physiol. 2018. PMID: 29513566 Free article.
We previously demonstrated that elevated ubiquitin ligase casitas B-lineage lymphoma-b (Cbl-b) resulted in the loss of muscle volume (Nakao R, Hirasaka K, Goto J, Ishidoh K, Yamada C, Ohno A, Okumura Y, Nonaka I, Yasutomo K, Baldwin KM, Kominami E, Higashibata A, Nagano K, Tanaka …
We previously demonstrated that elevated ubiquitin ligase casitas B-lineage lymphoma-b (Cbl-b) resulted in the loss of muscle volume (Nakao …
155 results