Biochemistry and structural studies of kynurenine 3-monooxygenase reveal allosteric inhibition by Ro 61-8048.
Gao J, Yao L, Xia T, Liao X, Zhu D, Xiang Y.
Gao J, et al. Among authors: xia t.
FASEB J. 2018 Apr;32(4):2036-2045. doi: 10.1096/fj.201700397RR. Epub 2018 Jan 5.
FASEB J. 2018.
PMID: 29208702
The unique binding sites distinguish Ro 61-8048 as a noncompetitive and highly selective inhibitor from other competitive inhibitors, which should facilitate further optimization of Ro 61-8048 and the development of new inhibitory drugs to hKMO.-Gao, J., Yao, L., Xia, T …
The unique binding sites distinguish Ro 61-8048 as a noncompetitive and highly selective inhibitor from other competitive inhibitors, which …