Chandy KG - Search Results

1

Structures of wild-type and H451N mutant human lymphocyte potassium channel K_V1.3.

Liu S, Zhao Y, Dong H, Xiao L, Zhang Y, Yang Y, Ong ST, Chandy KG, Zhang L, Tian C. Liu S, et al. Among authors: chandy kg. Cell Discov. 2021 Jun 1;7(1):39. doi: 10.1038/s41421-021-00269-y. Cell Discov. 2021. PMID: 34059645 Free PMC article. No abstract available.

2

Contributions of natural products to ion channel pharmacology.

Bajaj S, Ong ST, Chandy KG. Bajaj S, et al. Among authors: chandy kg. Nat Prod Rep. 2020 May 1;37(5):703-716. doi: 10.1039/c9np00056a. Epub 2020 Feb 17. Nat Prod Rep. 2020. PMID: 32065187 Review.

3

Modulation of Lymphocyte Potassium Channel K_V1.3 by Membrane-Penetrating, Joint-Targeting Immunomodulatory Plant Defensin.

Ong ST, Bajaj S, Tanner MR, Chang SC, Krishnarjuna B, Ng XR, Morales RAV, Chen MW, Luo D, Patel D, Yasmin S, Ng JJH, Zhuang Z, Nguyen HM, El Sahili A, Lescar J, Patil R, Charman SA, Robins EG, Goggi JL, Tan PW, Sadasivam P, Ramasamy B, Hartimath SV, Dhawan V, Bednenko J, Colussi P, Wulff H, Pennington MW, Kuyucak S, Norton RS, Beeton C, Chandy KG. Ong ST, et al. Among authors: chandy kg. ACS Pharmacol Transl Sci. 2020 May 14;3(4):720-736. doi: 10.1021/acsptsci.0c00035. eCollection 2020 Aug 14. ACS Pharmacol Transl Sci. 2020. PMID: 32832873 Free PMC article.

4

Extracellular K⁺ Dampens T Cell Functions: Implications for Immune Suppression in the Tumor Microenvironment.

Ong ST, Ng AS, Ng XR, Zhuang Z, Wong BHS, Prasannan P, Kok YJ, Bi X, Shim H, Wulff H, Chandy KG, Verma NK. Ong ST, et al. Among authors: chandy kg. Bioelectricity. 2019 Sep 1;1(3):169-179. doi: 10.1089/bioe.2019.0016. Epub 2019 Sep 16. Bioelectricity. 2019. PMID: 34471819 Free PMC article.

5

Rearrangement of a unique Kv1.3 selectivity filter conformation upon binding of a drug.

Tyagi A, Ahmed T, Jian S, Bajaj S, Ong ST, Goay SSM, Zhao Y, Vorobyov I, Tian C, Chandy KG, Bhushan S. Tyagi A, et al. Among authors: chandy kg. Proc Natl Acad Sci U S A. 2022 Feb 1;119(5):e2113536119. doi: 10.1073/pnas.2113536119. Proc Natl Acad Sci U S A. 2022. PMID: 35091471 Free PMC article.

6

Imaging Kv1.3 Expressing Memory T Cells as a Marker of Immunotherapy Response.

Goggi JL, Khanapur S, Ramasamy B, Hartimath SV, Rong TJ, Cheng P, Tan YX, Yeo XY, Jung S, Goay SSM, Ong ST, Hwang YY, Chandy KG, Robins EG. Goggi JL, et al. Among authors: chandy kg. Cancers (Basel). 2022 Feb 26;14(5):1217. doi: 10.3390/cancers14051217. Cancers (Basel). 2022. PMID: 35267526 Free PMC article.

7

Mechanisms Underlying C-type Inactivation in Kv Channels: Lessons From Structures of Human Kv1.3 and Fly Shaker-IR Channels.

Ong ST, Tyagi A, Chandy KG, Bhushan S. Ong ST, et al. Among authors: chandy kg. Front Pharmacol. 2022 Jun 27;13:924289. doi: 10.3389/fphar.2022.924289. eCollection 2022. Front Pharmacol. 2022. PMID: 35833027 Free PMC article. Review.

8

Structure of the voltage-gated potassium channel K_V1.3: Insights into the inactivated conformation and binding to therapeutic leads.

Chandy KG, Sanches K, Norton RS. Chandy KG, et al. Channels (Austin). 2023 Dec;17(1):2253104. doi: 10.1080/19336950.2023.2253104. Channels (Austin). 2023. PMID: 37695839 Free PMC article. Review.

9

Interaction of the Inhibitory Peptides ShK and HmK with the Voltage-Gated Potassium Channel K_V1.3: Role of Conformational Dynamics.

Sanches K, Prypoten V, Chandy KG, Chalmers DK, Norton RS. Sanches K, et al. Among authors: chandy kg. J Chem Inf Model. 2023 May 22;63(10):3043-3053. doi: 10.1021/acs.jcim.2c01237. Epub 2023 May 4. J Chem Inf Model. 2023. PMID: 37143234

10

Antibodies and venom peptides: new modalities for ion channels.

Wulff H, Christophersen P, Colussi P, Chandy KG, Yarov-Yarovoy V. Wulff H, et al. Among authors: chandy kg. Nat Rev Drug Discov. 2019 May;18(5):339-357. doi: 10.1038/s41573-019-0013-8. Nat Rev Drug Discov. 2019. PMID: 30728472 Free PMC article. Review.

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