Reuter K - Search Results

1

Targeting a Cryptic Pocket in a Protein-Protein Contact by Disulfide-Induced Rupture of a Homodimeric Interface.

Nguyen D, Xie X, Jakobi S, Terwesten F, Metz A, Nguyen TXP, Palchykov VA, Heine A, Reuter K, Klebe G. Nguyen D, et al. Among authors: reuter k. ACS Chem Biol. 2021 Jun 18;16(6):1090-1098. doi: 10.1021/acschembio.1c00296. Epub 2021 Jun 3. ACS Chem Biol. 2021. PMID: 34081441

2

Mutagenesis and crystallographic studies of Zymomonas mobilis tRNA-guanine transglycosylase to elucidate the role of serine 103 for enzymatic activity.

Grädler U, Ficner R, Garcia GA, Stubbs MT, Klebe G, Reuter K. Grädler U, et al. Among authors: reuter k. FEBS Lett. 1999 Jul 2;454(1-2):142-6. doi: 10.1016/s0014-5793(99)00793-0. FEBS Lett. 1999. PMID: 10413112 Free article.

Mutation of Ser90 to an alanine in Escherichia coli TGT leads to a dramatic reduction of enzymatic activity (Reuter, K. et al. (1994) Biochemistry 33, 7041-7046). To further clarify the role of this residue in the catalytic center, we have mutated the corresponding …

Mutation of Ser90 to an alanine in Escherichia coli TGT leads to a dramatic reduction of enzymatic activity (Reuter, K. et al. …

3

Screening orthologs as an important variable in crystallization: preliminary X-ray diffraction studies of the tRNA-modifying enzyme S-adenosyl-methionine:tRNA ribosyl transferase/isomerase.

Grimm C, Klebe G, Ficner R, Reuter K. Grimm C, et al. Among authors: reuter k. Acta Crystallogr D Biol Crystallogr. 2000 Apr;56(Pt 4):484-8. doi: 10.1107/s0907444900001244. Acta Crystallogr D Biol Crystallogr. 2000. PMID: 10739928

4

The crystal structure of 3alpha -hydroxysteroid dehydrogenase/carbonyl reductase from Comamonas testosteroni shows a novel oligomerization pattern within the short chain dehydrogenase/reductase family.

Grimm C, Maser E, Möbus E, Klebe G, Reuter K, Ficner R. Grimm C, et al. Among authors: reuter k. J Biol Chem. 2000 Dec 29;275(52):41333-9. doi: 10.1074/jbc.M007559200. J Biol Chem. 2000. PMID: 11007791 Free article.

5

A new target for shigellosis: rational design and crystallographic studies of inhibitors of tRNA-guanine transglycosylase.

Grädler U, Gerber HD, Goodenough-Lashua DM, Garcia GA, Ficner R, Reuter K, Stubbs MT, Klebe G. Grädler U, et al. Among authors: reuter k. J Mol Biol. 2001 Feb 23;306(3):455-67. doi: 10.1006/jmbi.2000.4256. J Mol Biol. 2001. PMID: 11178905

6

Crystal structure of 1-deoxy-D-xylulose-5-phosphate reductoisomerase, a crucial enzyme in the non-mevalonate pathway of isoprenoid biosynthesis.

Reuter K, Sanderbrand S, Jomaa H, Wiesner J, Steinbrecher I, Beck E, Hintz M, Klebe G, Stubbs MT. Reuter K, et al. J Biol Chem. 2002 Feb 15;277(7):5378-84. doi: 10.1074/jbc.M109500200. Epub 2001 Dec 7. J Biol Chem. 2002. PMID: 11741911 Free article.

7

Virtual screening for submicromolar leads of tRNA-guanine transglycosylase based on a new unexpected binding mode detected by crystal structure analysis.

Brenk R, Naerum L, Grädler U, Gerber HD, Garcia GA, Reuter K, Stubbs MT, Klebe G. Brenk R, et al. Among authors: reuter k. J Med Chem. 2003 Mar 27;46(7):1133-43. doi: 10.1021/jm0209937. J Med Chem. 2003. PMID: 12646024

8

Crystal structure of 2-methylisocitrate lyase (PrpB) from Escherichia coli and modelling of its ligand bound active centre.

Grimm C, Evers A, Brock M, Maerker C, Klebe G, Buckel W, Reuter K. Grimm C, et al. Among authors: reuter k. J Mol Biol. 2003 May 2;328(3):609-21. doi: 10.1016/s0022-2836(03)00358-9. J Mol Biol. 2003. PMID: 12706720

9

An essential role for aspartate 264 in catalysis by tRNA-guanine transglycosylase from Escherichia coli.

Kittendorf JD, Sgraja T, Reuter K, Klebe G, Garcia GA. Kittendorf JD, et al. Among authors: reuter k. J Biol Chem. 2003 Oct 24;278(43):42369-76. doi: 10.1074/jbc.M304323200. Epub 2003 Aug 8. J Biol Chem. 2003. PMID: 12909636 Free article.

10

Flexible adaptations in the structure of the tRNA-modifying enzyme tRNA-guanine transglycosylase and their implications for substrate selectivity, reaction mechanism and structure-based drug design.

Brenk R, Stubbs MT, Heine A, Reuter K, Klebe G. Brenk R, et al. Among authors: reuter k. Chembiochem. 2003 Oct 6;4(10):1066-77. doi: 10.1002/cbic.200300644. Chembiochem. 2003. PMID: 14523925

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