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Omecamtiv mecarbil does not prolong QTc intervals at therapeutic concentrations.
Trivedi A, Hsu CP, Jafarinasabian P, Terminello B, Zhang H, Flach S, Israel S, Brooks A, Xue H, Darpo B, Abbasi S, Dutta S, Lee E. Trivedi A, et al. Among authors: lee e. Br J Clin Pharmacol. 2022 Jan;88(1):187-198. doi: 10.1111/bcp.14939. Epub 2021 Jul 16. Br J Clin Pharmacol. 2022. PMID: 34131942 Free article. Clinical Trial.
Evaluation of drug-drug interaction potential between omecamtiv mecarbil and rosuvastatin, a BCRP substrate, with a clinical study in healthy subjects and using a physiologically-based pharmacokinetic model.
Trivedi A, Sohn W, Kulkarni P, Jafarinasabian P, Zhang H, Spring M, Flach S, Abbasi S, Wahlstrom J, Lee E, Dutta S. Trivedi A, et al. Among authors: lee e. Clin Transl Sci. 2021 Nov;14(6):2510-2520. doi: 10.1111/cts.13118. Epub 2021 Aug 20. Clin Transl Sci. 2021. PMID: 34415673 Free PMC article.
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