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Page 1
Implications of retinal effects observed in chronic toxicity studies on the clinical development of a CNS-active drug candidate.
Eichenbaum G, Zhou J, Kelley MF, Roosen W, Costa-Giomi P, Louden C, Di Prospero NA, Pandina G, Singh JB, Ford L, Moyer JA, Nork TM, Ver Hoeve JN, Aguirre GD. Eichenbaum G, et al. Among authors: roosen w. Regul Toxicol Pharmacol. 2014 Jul;69(2):187-200. doi: 10.1016/j.yrtph.2014.03.005. Epub 2014 Mar 26. Regul Toxicol Pharmacol. 2014. PMID: 24680767
Opportunities for use of one species for longer-term toxicology testing during drug development: A cross-industry evaluation.
Prior H, Baldrick P, Beken S, Booler H, Bower N, Brooker P, Brown P, Burlinson B, Burns-Naas LA, Casey W, Chapman M, Clarke D, de Haan L, Doehr O, Downes N, Flaherty M, Gellatly N, Moesgaard SG, Harris J, Holbrook M, Hui J, Jones D, Jones K, Kedar H, Mahl A, Manninen A, McGuire A, Mortimer-Cassen E, Peraza M, Pugsley MK, Richard J, Roberts R, Roosen W, Rothfuss A, Schoenmakers A, Sewell F, Weaver R, Weir L, Wolfreys A, Kimber I. Prior H, et al. Among authors: roosen w. Regul Toxicol Pharmacol. 2020 Jun;113:104624. doi: 10.1016/j.yrtph.2020.104624. Epub 2020 Feb 29. Regul Toxicol Pharmacol. 2020. PMID: 32126256 Free article.
A global pharmaceutical company initiative: an evidence-based approach to define the upper limit of body weight loss in short term toxicity studies.
Chapman K, Sewell F, Allais L, Delongeas JL, Donald E, Festag M, Kervyn S, Ockert D, Nogues V, Palmer H, Popovic M, Roosen W, Schoenmakers A, Somers K, Stark C, Stei P, Robinson S. Chapman K, et al. Among authors: roosen w. Regul Toxicol Pharmacol. 2013 Oct;67(1):27-38. doi: 10.1016/j.yrtph.2013.04.003. Epub 2013 Apr 19. Regul Toxicol Pharmacol. 2013. PMID: 23602904 Free article.
Intravenous Administration of Ad26.COV2.S Does Not Induce Thrombocytopenia or Thrombotic Events or Affect SARS-CoV-2 Spike Protein Bioavailability in Blood Compared with Intramuscular Vaccination in Rabbits.
Khan S, Marquez-Martinez S, Erkens T, de Wilde A, Costes LMM, Vinken P, De Jonghe S, Roosen W, Talia C, Chamanza R, Serroyen J, Tolboom J, Zahn RC, Wegmann F. Khan S, et al. Among authors: roosen w. Vaccines (Basel). 2023 Nov 30;11(12):1792. doi: 10.3390/vaccines11121792. Vaccines (Basel). 2023. PMID: 38140195 Free PMC article.
The Biodistribution of the Spike Protein after Ad26.COV2.S Vaccination Is Unlikely to Play a Role in Vaccine-Induced Immune Thrombotic Thrombocytopenia.
Marquez-Martinez S, Khan S, Lubbe JV, Solforosi L, Costes LMM, Choi Y, Boedhoe S, Verslegers M, Heerden MV, Roosen W, Jonghe S, Kristyanto H, Rezelj V, Hendriks J, Serroyen J, Tolboom J, Wegmann F, Zahn RC. Marquez-Martinez S, et al. Among authors: roosen w. Vaccines (Basel). 2024 May 20;12(5):559. doi: 10.3390/vaccines12050559. Vaccines (Basel). 2024. PMID: 38793810 Free PMC article.