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Advancing targeted protein degradation for cancer therapy.
Dale B, Cheng M, Park KS, Kaniskan HÜ, Xiong Y, Jin J. Dale B, et al. Among authors: jin j. Nat Rev Cancer. 2021 Oct;21(10):638-654. doi: 10.1038/s41568-021-00365-x. Epub 2021 Jun 15. Nat Rev Cancer. 2021. PMID: 34131295 Free PMC article. Review.
Topoisomerase inhibitors unsilence the dormant allele of Ube3a in neurons.
Huang HS, Allen JA, Mabb AM, King IF, Miriyala J, Taylor-Blake B, Sciaky N, Dutton JW Jr, Lee HM, Chen X, Jin J, Bridges AS, Zylka MJ, Roth BL, Philpot BD. Huang HS, et al. Among authors: jin j. Nature. 2011 Dec 21;481(7380):185-9. doi: 10.1038/nature10726. Nature. 2011. PMID: 22190039 Free PMC article.
Selective inhibitors of protein methyltransferases.
Kaniskan HÜ, Konze KD, Jin J. Kaniskan HÜ, et al. Among authors: jin j. J Med Chem. 2015 Feb 26;58(4):1596-629. doi: 10.1021/jm501234a. Epub 2014 Dec 2. J Med Chem. 2015. PMID: 25406853 Free PMC article.
Chemical probes of histone lysine methyltransferases.
Kaniskan HÜ, Jin J. Kaniskan HÜ, et al. Among authors: jin j. ACS Chem Biol. 2015 Jan 16;10(1):40-50. doi: 10.1021/cb500785t. Epub 2014 Nov 25. ACS Chem Biol. 2015. PMID: 25423077 Free PMC article. Review.
A potent, selective and cell-active allosteric inhibitor of protein arginine methyltransferase 3 (PRMT3).
Kaniskan HÜ, Szewczyk MM, Yu Z, Eram MS, Yang X, Schmidt K, Luo X, Dai M, He F, Zang I, Lin Y, Kennedy S, Li F, Dobrovetsky E, Dong A, Smil D, Min SJ, Landon M, Lin-Jones J, Huang XP, Roth BL, Schapira M, Atadja P, Barsyte-Lovejoy D, Arrowsmith CH, Brown PJ, Zhao K, Jin J, Vedadi M. Kaniskan HÜ, et al. Among authors: jin j. Angew Chem Int Ed Engl. 2015 Apr 20;54(17):5166-70. doi: 10.1002/anie.201412154. Epub 2015 Feb 27. Angew Chem Int Ed Engl. 2015. PMID: 25728001 Free PMC article.
A Potent, Selective, and Cell-Active Inhibitor of Human Type I Protein Arginine Methyltransferases.
Eram MS, Shen Y, Szewczyk M, Wu H, Senisterra G, Li F, Butler KV, Kaniskan HÜ, Speed BA, Dela Seña C, Dong A, Zeng H, Schapira M, Brown PJ, Arrowsmith CH, Barsyte-Lovejoy D, Liu J, Vedadi M, Jin J. Eram MS, et al. Among authors: jin j. ACS Chem Biol. 2016 Mar 18;11(3):772-781. doi: 10.1021/acschembio.5b00839. Epub 2015 Dec 8. ACS Chem Biol. 2016. PMID: 26598975 Free PMC article.
Discovery of a Potent, Selective, and Cell-Active Dual Inhibitor of Protein Arginine Methyltransferase 4 and Protein Arginine Methyltransferase 6.
Shen Y, Szewczyk MM, Eram MS, Smil D, Kaniskan HÜ, de Freitas RF, Senisterra G, Li F, Schapira M, Brown PJ, Arrowsmith CH, Barsyte-Lovejoy D, Liu J, Vedadi M, Jin J. Shen Y, et al. Among authors: jin j. J Med Chem. 2016 Oct 13;59(19):9124-9139. doi: 10.1021/acs.jmedchem.6b01033. Epub 2016 Sep 15. J Med Chem. 2016. PMID: 27584694 Free PMC article.
Inhibitors of Protein Methyltransferases and Demethylases.
Kaniskan HÜ, Martini ML, Jin J. Kaniskan HÜ, et al. Among authors: jin j. Chem Rev. 2018 Feb 14;118(3):989-1068. doi: 10.1021/acs.chemrev.6b00801. Epub 2017 Mar 24. Chem Rev. 2018. PMID: 28338320 Free PMC article. Review.
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