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126 results

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Systemic immune response against the oral pathogens Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans is associated with the formation and rupture of intracranial aneurysms.
Hallikainen J, Pyysalo M, Keränen S, Kellokoski J, Koivisto T, Suominen AL, Pussinen P, Pessi T, Frösen J. Hallikainen J, et al. Among authors: keranen s. Eur J Neurol. 2021 Sep;28(9):3089-3099. doi: 10.1111/ene.14986. Epub 2021 Jul 8. Eur J Neurol. 2021. PMID: 34145948
Role of oral pathogens in the pathogenesis of intracranial aneurysm: review of existing evidence and potential mechanisms.
Hallikainen J, Keränen S, Savolainen J, Närhi M, Suominen AL, Ylöstalo P, Kellokoski J, Pyysalo M, Pussinen P, Rauramaa T, Frösen J. Hallikainen J, et al. Among authors: keranen s. Neurosurg Rev. 2021 Feb;44(1):239-247. doi: 10.1007/s10143-020-01253-y. Epub 2020 Feb 7. Neurosurg Rev. 2021. PMID: 32034564 Free PMC article. Review.
Cyclo-oxygenase 2, a putative mediator of vessel remodeling, is expressed in the brain AVM vessels and associates with inflammation.
Keränen S, Suutarinen S, Mallick R, Laakkonen JP, Guo D, Pawlikowska L, Jahromi BR, Rauramaa T, Ylä-Herttuala S, Marchuk D, Krings T, Koivisto T, Lawton M, Radovanovic I, Kim H, Faughnan ME, Frösen J. Keränen S, et al. Acta Neurochir (Wien). 2021 Sep;163(9):2503-2514. doi: 10.1007/s00701-021-04895-z. Epub 2021 Jun 29. Acta Neurochir (Wien). 2021. PMID: 34185176 Free PMC article.
CNS-associated macrophages contribute to intracerebral aneurysm pathophysiology.
Glavan M, Jelic A, Levard D, Frösen J, Keränen S, Franx BAA, Bras AR, Louet ER, Dénes Á, Merlini M, Vivien D, Rubio M. Glavan M, et al. Among authors: keranen s. Acta Neuropathol Commun. 2024 Mar 18;12(1):43. doi: 10.1186/s40478-024-01756-5. Acta Neuropathol Commun. 2024. PMID: 38500201 Free PMC article.
ErbB signaling is a potential therapeutic target for vascular lesions with fibrous component.
Jauhiainen S, Ilmonen H, Vuola P, Rasinkangas H, Pulkkinen HH, Keränen S, Kiema M, Liikkanen JJ, Laham-Karam N, Laidinen S, Beter M, Aavik E, Lappalainen K, Lohi J, Aronniemi J, Örd T, Kaikkonen MU, Salminen P, Tukiainen E, Ylä-Herttuala S, Laakkonen JP. Jauhiainen S, et al. Among authors: keranen s. Elife. 2023 May 18;12:e82543. doi: 10.7554/eLife.82543. Elife. 2023. PMID: 37199488 Free PMC article.
Tucatinib plus trastuzumab for chemotherapy-refractory, HER2-positive, RAS wild-type unresectable or metastatic colorectal cancer (MOUNTAINEER): a multicentre, open-label, phase 2 study.
Strickler JH, Cercek A, Siena S, André T, Ng K, Van Cutsem E, Wu C, Paulson AS, Hubbard JM, Coveler AL, Fountzilas C, Kardosh A, Kasi PM, Lenz HJ, Ciombor KK, Elez E, Bajor DL, Cremolini C, Sanchez F, Stecher M, Feng W, Bekaii-Saab TS; MOUNTAINEER investigators. Strickler JH, et al. Lancet Oncol. 2023 May;24(5):496-508. doi: 10.1016/S1470-2045(23)00150-X. Lancet Oncol. 2023. PMID: 37142372 Clinical Trial.
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