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Safety and efficacy of pioglitazone for the delay of cognitive impairment in people at risk of Alzheimer's disease (TOMMORROW): a prognostic biomarker study and a phase 3, randomised, double-blind, placebo-controlled trial.
Burns DK, Alexander RC, Welsh-Bohmer KA, Culp M, Chiang C, O'Neil J, Evans RM, Harrigan P, Plassman BL, Burke JR, Wu J, Lutz MW, Haneline S, Schwarz AJ, Schneider LS, Yaffe K, Saunders AM, Ratti E; TOMMORROW study investigators. Burns DK, et al. Among authors: lutz mw. Lancet Neurol. 2021 Jul;20(7):537-547. doi: 10.1016/S1474-4422(21)00043-0. Lancet Neurol. 2021. PMID: 34146512 Clinical Trial.
Genetic variation at a single locus and age of onset for Alzheimer's disease.
Lutz MW, Crenshaw DG, Saunders AM, Roses AD. Lutz MW, et al. Alzheimers Dement. 2010 Mar;6(2):125-31. doi: 10.1016/j.jalz.2010.01.011. Alzheimers Dement. 2010. PMID: 20298972 Free PMC article.
The significant finding discussed here is that a variable-length, deoxythymidine homopolymer (poly-T) within intron 6 of the TOMM40 gene is associated with the age of onset of LOAD [Roses AD, Lutz MW, Amrine-Madsen H, Saunders AM, Crenshaw DG, Sundseth SS, et al. A …
The significant finding discussed here is that a variable-length, deoxythymidine homopolymer (poly-T) within intron 6 of the TOMM40 gene is …
The importance of being connected.
Lutz MW, Crenshaw DG, Saunders AM, Roses AD. Lutz MW, et al. J Alzheimers Dis. 2011;24(2):247-51. doi: 10.3233/JAD-2010-101765. J Alzheimers Dis. 2011. PMID: 21206004 Free article. No abstract available.
Characterization of the poly-T variant in the TOMM40 gene in diverse populations.
Linnertz C, Saunders AM, Lutz MW, Crenshaw DM, Grossman I, Burns DK, Whitfield KE, Hauser MA, McCarthy JJ, Ulmer M, Allingham R, Welsh-Bohmer KA, Roses AD, Chiba-Falek O. Linnertz C, et al. Among authors: lutz mw. PLoS One. 2012;7(2):e30994. doi: 10.1371/journal.pone.0030994. Epub 2012 Feb 16. PLoS One. 2012. PMID: 22359560 Free PMC article.
Longitudinal modeling of cognitive aging and the TOMM40 effect.
Caselli RJ, Dueck AC, Huentelman MJ, Lutz MW, Saunders AM, Reiman EM, Roses AD. Caselli RJ, et al. Among authors: lutz mw. Alzheimers Dement. 2012 Nov;8(6):490-5. doi: 10.1016/j.jalz.2011.11.006. Alzheimers Dement. 2012. PMID: 23102119 Free PMC article.
Using genetics to enable studies on the prevention of Alzheimer's disease.
Crenshaw DG, Gottschalk WK, Lutz MW, Grossman I, Saunders AM, Burke JR, Welsh-Bohmer KA, Brannan SK, Burns DK, Roses AD. Crenshaw DG, et al. Among authors: lutz mw. Clin Pharmacol Ther. 2013 Feb;93(2):177-85. doi: 10.1038/clpt.2012.222. Epub 2012 Nov 7. Clin Pharmacol Ther. 2013. PMID: 23249780 Free PMC article.
123 results