Alexander JAN - Search Results

1

PBP4-mediated β-lactam resistance among clinical strains of Staphylococcus aureus.

Satishkumar N, Alexander JAN, Poon R, Buggeln E, Argudín MA, Strynadka NCJ, Chatterjee SS. Satishkumar N, et al. Among authors: alexander jan. J Antimicrob Chemother. 2021 Aug 12;76(9):2268-2272. doi: 10.1093/jac/dkab201. J Antimicrob Chemother. 2021. PMID: 34151961 Free PMC article.

2

Structural and Kinetic Characterization of Diazabicyclooctanes as Dual Inhibitors of Both Serine-β-Lactamases and Penicillin-Binding Proteins.

King AM, King DT, French S, Brouillette E, Asli A, Alexander JA, Vuckovic M, Maiti SN, Parr TR Jr, Brown ED, Malouin F, Strynadka NC, Wright GD. King AM, et al. ACS Chem Biol. 2016 Apr 15;11(4):864-8. doi: 10.1021/acschembio.5b00944. Epub 2016 Jan 14. ACS Chem Biol. 2016. PMID: 26731698

3

High-Level Resistance of Staphylococcus aureus to β-Lactam Antibiotics Mediated by Penicillin-Binding Protein 4 (PBP4).

Hamilton SM, Alexander JAN, Choo EJ, Basuino L, da Costa TM, Severin A, Chung M, Aedo S, Strynadka NCJ, Tomasz A, Chatterjee SS, Chambers HF. Hamilton SM, et al. Among authors: alexander jan. Antimicrob Agents Chemother. 2017 May 24;61(6):e02727-16. doi: 10.1128/AAC.02727-16. Print 2017 Jun. Antimicrob Agents Chemother. 2017. PMID: 28373193 Free PMC article.

4

PBP4 activity and its overexpression are necessary for PBP4-mediated high-level β-lactam resistance.

Basuino L, Jousselin A, Alexander JAN, Strynadka NCJ, Pinho MG, Chambers HF, Chatterjee SS. Basuino L, et al. Among authors: alexander jan. J Antimicrob Chemother. 2018 May 1;73(5):1177-1180. doi: 10.1093/jac/dkx531. J Antimicrob Chemother. 2018. PMID: 29360990 Free PMC article.

5

Structural and kinetic analyses of penicillin-binding protein 4 (PBP4)-mediated antibiotic resistance in Staphylococcus aureus.

Alexander JAN, Chatterjee SS, Hamilton SM, Eltis LD, Chambers HF, Strynadka NCJ. Alexander JAN, et al. J Biol Chem. 2018 Dec 21;293(51):19854-19865. doi: 10.1074/jbc.RA118.004952. Epub 2018 Oct 26. J Biol Chem. 2018. PMID: 30366985 Free PMC article.

6

Recognition of Peptidoglycan Fragments by the Transpeptidase PBP4 From Staphylococcus aureus.

Maya-Martinez R, Alexander JAN, Otten CF, Ayala I, Vollmer D, Gray J, Bougault CM, Burt A, Laguri C, Fonvielle M, Arthur M, Strynadka NCJ, Vollmer W, Simorre JP. Maya-Martinez R, et al. Among authors: alexander jan. Front Microbiol. 2019 Jan 18;9:3223. doi: 10.3389/fmicb.2018.03223. eCollection 2018. Front Microbiol. 2019. PMID: 30713527 Free PMC article.

7

Structural analysis of avibactam-mediated activation of the bla and mec divergons in methicillin-resistant Staphylococcus aureus.

Alexander JAN, Radaeva M, King DT, Chambers HF, Cherkasov A, Chatterjee SS, Strynadka NCJ. Alexander JAN, et al. J Biol Chem. 2020 Aug 7;295(32):10870-10884. doi: 10.1074/jbc.RA120.013029. Epub 2020 Jun 9. J Biol Chem. 2020. PMID: 32518158 Free PMC article.

8

Structural basis of broad-spectrum β-lactam resistance in Staphylococcus aureus.

Alexander JAN, Worrall LJ, Hu J, Vuckovic M, Satishkumar N, Poon R, Sobhanifar S, Rosell FI, Jenkins J, Chiang D, Mosimann WA, Chambers HF, Paetzel M, Chatterjee SS, Strynadka NCJ. Alexander JAN, et al. Nature. 2023 Jan;613(7943):375-382. doi: 10.1038/s41586-022-05583-3. Epub 2023 Jan 4. Nature. 2023. PMID: 36599987 Free PMC article.

9

Cyanide and Cyanogenic Compounds-Toxicity, Molecular Targets, and Therapeutic Agents.

Lachowicz JI, Alexander J, Aaseth JO. Lachowicz JI, et al. Among authors: alexander j. Biomolecules. 2024 Nov 7;14(11):1420. doi: 10.3390/biom14111420. Biomolecules. 2024. PMID: 39595596 Free PMC article. Review.

10

The Importance of Vitamin K and the Combination of Vitamins K and D for Calcium Metabolism and Bone Health: A Review.

Aaseth JO, Finnes TE, Askim M, Alexander J. Aaseth JO, et al. Among authors: alexander j. Nutrients. 2024 Jul 25;16(15):2420. doi: 10.3390/nu16152420. Nutrients. 2024. PMID: 39125301 Free PMC article. Review.

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