Kapoor A - Search Results

1

A promising chemical series of positive allosteric modulators of the μ-opioid receptor that enhance the antinociceptive efficacy of opioids but not their adverse effects.

Pryce KD, Kang HJ, Sakloth F, Liu Y, Khan S, Toth K, Kapoor A, Nicolais A, Che T, Qin L, Bertherat F, Kaniskan HÜ, Jin J, Cameron MD, Roth BL, Zachariou V, Filizola M. Pryce KD, et al. Among authors: kapoor a. Neuropharmacology. 2021 Sep 1;195:108673. doi: 10.1016/j.neuropharm.2021.108673. Epub 2021 Jun 18. Neuropharmacology. 2021. PMID: 34153316 Free PMC article.

2

Atomic-Level Characterization of the Methadone-Stabilized Active Conformation of µ-Opioid Receptor.

Kapoor A, Provasi D, Filizola M. Kapoor A, et al. Mol Pharmacol. 2020 Oct;98(4):475-486. doi: 10.1124/mol.119.119339. Epub 2020 Jul 17. Mol Pharmacol. 2020. PMID: 32680919 Free PMC article.

3

Dynamic and Kinetic Elements of µ-Opioid Receptor Functional Selectivity.

Kapoor A, Martinez-Rosell G, Provasi D, de Fabritiis G, Filizola M. Kapoor A, et al. Sci Rep. 2017 Sep 12;7(1):11255. doi: 10.1038/s41598-017-11483-8. Sci Rep. 2017. PMID: 28900175 Free PMC article.

4

Predicted Mode of Binding to and Allosteric Modulation of the μ-Opioid Receptor by Kratom's Alkaloids with Reported Antinociception In Vivo.

Zhou Y, Ramsey S, Provasi D, El Daibani A, Appourchaux K, Chakraborty S, Kapoor A, Che T, Majumdar S, Filizola M. Zhou Y, et al. Among authors: kapoor a. Biochemistry. 2021 May 11;60(18):1420-1429. doi: 10.1021/acs.biochem.0c00658. Epub 2020 Dec 4. Biochemistry. 2021. PMID: 33274929 Free PMC article.

5

Synthetic and Receptor Signaling Explorations of the Mitragyna Alkaloids: Mitragynine as an Atypical Molecular Framework for Opioid Receptor Modulators.

Kruegel AC, Gassaway MM, Kapoor A, Váradi A, Majumdar S, Filizola M, Javitch JA, Sames D. Kruegel AC, et al. Among authors: kapoor a. J Am Chem Soc. 2016 Jun 1;138(21):6754-64. doi: 10.1021/jacs.6b00360. Epub 2016 May 18. J Am Chem Soc. 2016. PMID: 27192616 Free PMC article.

6

SOX11 Inhibitors Are Cytotoxic in Mantle Cell Lymphoma.

Jatiani SS, Christie S, Leshchenko VV, Jain R, Kapoor A, Bisignano P, Lee C, Kaniskan HÜ, Edwards D, Meng F, Laganà A, Youssef Y, Wiestner A, Alinari L, Jin J, Filizola M, Aggarwal AK, Parekh S. Jatiani SS, et al. Among authors: kapoor a. Clin Cancer Res. 2021 Aug 15;27(16):4652-4663. doi: 10.1158/1078-0432.CCR-20-5039. Epub 2021 Jun 22. Clin Cancer Res. 2021. PMID: 34158358 Free PMC article.

7

Identification of a small-molecule ligand that activates the neuropeptide receptor GPR171 and increases food intake.

Wardman JH, Gomes I, Bobeck EN, Stockert JA, Kapoor A, Bisignano P, Gupta A, Mezei M, Kumar S, Filizola M, Devi LA. Wardman JH, et al. Among authors: kapoor a. Sci Signal. 2016 May 31;9(430):ra55. doi: 10.1126/scisignal.aac8035. Sci Signal. 2016. PMID: 27245612 Free PMC article.

8

Molecular mechanism of setron-mediated inhibition of full-length 5-HT_3A receptor.

Basak S, Gicheru Y, Kapoor A, Mayer ML, Filizola M, Chakrapani S. Basak S, et al. Among authors: kapoor a. Nat Commun. 2019 Jul 19;10(1):3225. doi: 10.1038/s41467-019-11142-8. Nat Commun. 2019. PMID: 31324772 Free PMC article.

9

High-resolution structures of multiple 5-HT_3AR-setron complexes reveal a novel mechanism of competitive inhibition.

Basak S, Kumar A, Ramsey S, Gibbs E, Kapoor A, Filizola M, Chakrapani S. Basak S, et al. Among authors: kapoor a. Elife. 2020 Oct 16;9:e57870. doi: 10.7554/eLife.57870. Elife. 2020. PMID: 33063666 Free PMC article.

10

Structure-based characterization of novel TRPV5 inhibitors.

Hughes TE, Del Rosario JS, Kapoor A, Yazici AT, Yudin Y, Fluck EC 3rd, Filizola M, Rohacs T, Moiseenkova-Bell VY. Hughes TE, et al. Among authors: kapoor a. Elife. 2019 Oct 25;8:e49572. doi: 10.7554/eLife.49572. Elife. 2019. PMID: 31647410 Free PMC article.

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