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A promising chemical series of positive allosteric modulators of the μ-opioid receptor that enhance the antinociceptive efficacy of opioids but not their adverse effects.
Pryce KD, Kang HJ, Sakloth F, Liu Y, Khan S, Toth K, Kapoor A, Nicolais A, Che T, Qin L, Bertherat F, Kaniskan HÜ, Jin J, Cameron MD, Roth BL, Zachariou V, Filizola M. Pryce KD, et al. Among authors: zachariou v. Neuropharmacology. 2021 Sep 1;195:108673. doi: 10.1016/j.neuropharm.2021.108673. Epub 2021 Jun 18. Neuropharmacology. 2021. PMID: 34153316 Free PMC article.
RGS9-2 Modulates Responses to Oxycodone in Pain-Free and Chronic Pain States.
Gaspari S, Cogliani V, Manouras L, Anderson EM, Mitsi V, Avrampou K, Carr FB, Zachariou V. Gaspari S, et al. Among authors: zachariou v. Neuropsychopharmacology. 2017 Jun;42(7):1548-1556. doi: 10.1038/npp.2017.4. Epub 2017 Jan 11. Neuropsychopharmacology. 2017. PMID: 28074831 Free PMC article.
RGS4 Maintains Chronic Pain Symptoms in Rodent Models.
Avrampou K, Pryce KD, Ramakrishnan A, Sakloth F, Gaspari S, Serafini RA, Mitsi V, Polizu C, Swartz C, Ligas B, Richards A, Shen L, Carr FB, Zachariou V. Avrampou K, et al. Among authors: zachariou v. J Neurosci. 2019 Oct 16;39(42):8291-8304. doi: 10.1523/JNEUROSCI.3154-18.2019. Epub 2019 Jul 15. J Neurosci. 2019. PMID: 31308097 Free PMC article.
Regulators of G Protein Signaling in Analgesia and Addiction.
Sakloth F, Polizu C, Bertherat F, Zachariou V. Sakloth F, et al. Among authors: zachariou v. Mol Pharmacol. 2020 Dec;98(6):739-750. doi: 10.1124/mol.119.119206. Epub 2020 May 30. Mol Pharmacol. 2020. PMID: 32474445 Free PMC article. Review.
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[No authors listed] [No authors listed] PMID: 35552946
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[No authors listed] [No authors listed] PMID: 35552957
121 results