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Phase I First-in-Human Dose Escalation Study of the oral SF3B1 modulator H3B-8800 in myeloid neoplasms.
Steensma DP, Wermke M, Klimek VM, Greenberg PL, Font P, Komrokji RS, Yang J, Brunner AM, Carraway HE, Ades L, Al-Kali A, Alonso-Dominguez JM, Alfonso-Piérola A, Coombs CC, Deeg HJ, Flinn I, Foran JM, Garcia-Manero G, Maris MB, McMasters M, Micol JB, De Oteyza JP, Thol F, Wang ES, Watts JM, Taylor J, Stone R, Gourineni V, Marino AJ, Yao H, Destenaves B, Yuan X, Yu K, Dar S, Ohanjanian L, Kuida K, Xiao J, Scholz C, Gualberto A, Platzbecker U. Steensma DP, et al. Among authors: yao h. Leukemia. 2021 Dec;35(12):3542-3550. doi: 10.1038/s41375-021-01328-9. Epub 2021 Jun 25. Leukemia. 2021. PMID: 34172893 Free PMC article. Clinical Trial.
H3B-8800, an orally available small-molecule splicing modulator, induces lethality in spliceosome-mutant cancers.
Seiler M, Yoshimi A, Darman R, Chan B, Keaney G, Thomas M, Agrawal AA, Caleb B, Csibi A, Sean E, Fekkes P, Karr C, Klimek V, Lai G, Lee L, Kumar P, Lee SC, Liu X, Mackenzie C, Meeske C, Mizui Y, Padron E, Park E, Pazolli E, Peng S, Prajapati S, Taylor J, Teng T, Wang J, Warmuth M, Yao H, Yu L, Zhu P, Abdel-Wahab O, Smith PG, Buonamici S. Seiler M, et al. Among authors: yao h. Nat Med. 2018 May;24(4):497-504. doi: 10.1038/nm.4493. Epub 2018 Feb 19. Nat Med. 2018. PMID: 29457796 Free PMC article.
SF3B1 as therapeutic target in FLT3/ITD positive acute myeloid leukemia.
van der Werf I, Wojtuszkiewicz A, Yao H, Sciarrillo R, Meggendorfer M, Hutter S, Walter W, Janssen J, Kern W, Haferlach C, Haferlach T, Jansen G, Kaspers GJL, Groen R, Ossenkoppele G, Cloos J. van der Werf I, et al. Among authors: yao h. Leukemia. 2021 Sep;35(9):2698-2702. doi: 10.1038/s41375-021-01273-7. Epub 2021 May 17. Leukemia. 2021. PMID: 34002025 Free PMC article. No abstract available.
Author Correction: SF3B1 as therapeutic target in FLT3/ITD positive acute myeloid leukemia.
van der Werf I, Wojtuszkiewicz A, Yao H, Sciarrillo R, Meggendorfer M, Hutter S, Walter W, Janssen J, Kern W, Haferlach C, Haferlach T, Jansen G, Kaspers GJL, Groen R, Ossenkoppele G, Cloos J. van der Werf I, et al. Among authors: yao h. Leukemia. 2021 Sep;35(9):2735. doi: 10.1038/s41375-021-01340-z. Leukemia. 2021. PMID: 34272482 Free PMC article. No abstract available.
Pharmacologic Activation of STING in the Bladder Induces Potent Antitumor Immunity in Non-Muscle Invasive Murine Bladder Cancer.
Huang KC, Chanda D, McGrath S, Dixit V, Zhang C, Wu J, Tendyke K, Yao H, Hukkanen R, Taylor N, Verbel D, Kim DS, Endo A, Noland TA, Chen Y, Matijevic M, Wang J, Hutz J, Sarwar N, Fang FG, Bao X. Huang KC, et al. Among authors: yao h. Mol Cancer Ther. 2022 Jun 1;21(6):914-924. doi: 10.1158/1535-7163.MCT-21-0780. Mol Cancer Ther. 2022. PMID: 35313332
Lignans from Schisandra chinensis (Turcz.) Baill ameliorates cognitive impairment in Alzheimer's disease and alleviates ferroptosis by activating the Nrf2/FPN1 signaling pathway and regulating iron levels.
Meng X, Zhao W, Yang R, Xu SQ, Wang SY, Li MM, Jiang YK, Hao ZC, Guan W, Kuang HX, Chen QS, Yao HY, Yan JJ, Yang BY, Liu Y. Meng X, et al. Among authors: yao hy. J Ethnopharmacol. 2025 Jan 9:119335. doi: 10.1016/j.jep.2025.119335. Online ahead of print. J Ethnopharmacol. 2025. PMID: 39798677
8,189 results