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A concise route to MK-4482 (EIDD-2801) from cytidine.
Vasudevan N , Ahlqvist GP , McGeough CP , Paymode DJ , Cardoso FSP , Lucas T , Dietz JP , Opatz T , Jamison TF , Gupton FB , Snead DR . Vasudevan N , et al. Among authors: snead dr. Chem Commun (Camb). 2020 Nov 11;56(87):13363-13364. doi: 10.1039/d0cc05944g. Epub 2020 Oct 8. Chem Commun (Camb). 2020. PMID: 33030468
Toward a Practical, Nonenzymatic Process for Investigational COVID-19 Antiviral Molnupiravir from Cytidine: Supply-Centered Synthesis.
Gopalsamuthiram V, Kadam AL, Noble JK, Snead DR, Williams C, Jamison TF, Senanayake C, Yadaw AK, Roy S, Sirasani G, Gupton BF, Burns J, Cook DW, Stringham RW, Ahmad S, Krack R. Gopalsamuthiram V, et al. Among authors: snead dr. Org Process Res Dev. 2021 Dec 17;25(12):2679-2685. doi: 10.1021/acs.oprd.1c00219. Epub 2021 Dec 9. Org Process Res Dev. 2021. PMID: 34955627 Free PMC article. Review.
Development of a Practical Synthesis of the 8-FDC Fragment of OPC-167832.
Gopalsamuthiram V, Ho DB, Peck CL, Natarajan V, Agrawal T, Burns JM, Bachert J, Cook DW, Stringham RW, Nelson R, Ahmad S, Gupton BF, Snead DR, McQuade DT, Vaidyanathan R, Donsbach K, Sieber JD. Gopalsamuthiram V, et al. Among authors: snead dr. ACS Omega. 2022 Feb 18;7(8):7223-7228. doi: 10.1021/acsomega.1c06996. eCollection 2022 Mar 1. ACS Omega. 2022. PMID: 35252712 Free PMC article.
Practical and Scalable Two-Step Process for 6-(2-Fluoro-4-nitrophenyl)-2-oxa-6-azaspiro[3.3]heptane: A Key Intermediate of the Potent Antibiotic Drug Candidate TBI-223.
Cardoso FSP, Kadam AL, Nelson RC, Tomlin JW, Dahal D, Kuehner CS, Gudvangen G, Arduengo AJ 3rd, Burns JM, Aleshire SL, Snead DR, Qu F, Belmore K, Ahmad S, Agrawal T, Sieber JD, Donsbach KO. Cardoso FSP, et al. Among authors: snead dr. Org Process Res Dev. 2023 Jul 12;27(7):1390-1399. doi: 10.1021/acs.oprd.3c00148. eCollection 2023 Jul 21. Org Process Res Dev. 2023. PMID: 37496954 Free PMC article.
61 results