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Page 1
Activation of the hypothalamic-pituitary-adrenal axis by exogenous and endogenous GDF15.
Cimino I, Kim H, Tung YCL, Pedersen K, Rimmington D, Tadross JA, Kohnke SN, Neves-Costa A, Barros A, Joaquim S, Bennett D, Melvin A, Lockhart SM, Rostron AJ, Scott J, Liu H, Burling K, Barker P, Clatworthy MR, Lee EC, Simpson AJ, Yeo GSH, Moita LF, Bence KK, Jørgensen SB, Coll AP, Breen DM, O'Rahilly S. Cimino I, et al. Among authors: jorgensen sb. Proc Natl Acad Sci U S A. 2021 Jul 6;118(27):e2106868118. doi: 10.1073/pnas.2106868118. Proc Natl Acad Sci U S A. 2021. PMID: 34187898 Free PMC article.
GFRAL is the receptor for GDF15 and is required for the anti-obesity effects of the ligand.
Yang L, Chang CC, Sun Z, Madsen D, Zhu H, Padkjær SB, Wu X, Huang T, Hultman K, Paulsen SJ, Wang J, Bugge A, Frantzen JB, Nørgaard P, Jeppesen JF, Yang Z, Secher A, Chen H, Li X, John LM, Shan B, He Z, Gao X, Su J, Hansen KT, Yang W, Jørgensen SB. Yang L, et al. Among authors: jorgensen sb. Nat Med. 2017 Oct;23(10):1158-1166. doi: 10.1038/nm.4394. Epub 2017 Aug 28. Nat Med. 2017. PMID: 28846099
Pharmacological but not physiological GDF15 suppresses feeding and the motivation to exercise.
Klein AB, Nicolaisen TS, Ørtenblad N, Gejl KD, Jensen R, Fritzen AM, Larsen EL, Karstoft K, Poulsen HE, Morville T, Sahl RE, Helge JW, Lund J, Falk S, Lyngbæk M, Ellingsgaard H, Pedersen BK, Lu W, Finan B, Jørgensen SB, Seeley RJ, Kleinert M, Kiens B, Richter EA, Clemmensen C. Klein AB, et al. Among authors: jorgensen sb. Nat Commun. 2021 Feb 15;12(1):1041. doi: 10.1038/s41467-021-21309-x. Nat Commun. 2021. PMID: 33589633 Free PMC article.
The anorectic actions of the TGFβ cytokine MIC-1/GDF15 require an intact brainstem area postrema and nucleus of the solitary tract.
Tsai VW, Manandhar R, Jørgensen SB, Lee-Ng KK, Zhang HP, Marquis CP, Jiang L, Husaini Y, Lin S, Sainsbury A, Sawchenko PE, Brown DA, Breit SN. Tsai VW, et al. Among authors: jorgensen sb. PLoS One. 2014 Jun 27;9(6):e100370. doi: 10.1371/journal.pone.0100370. eCollection 2014. PLoS One. 2014. PMID: 24971956 Free PMC article.
TGF-b superfamily cytokine MIC-1/GDF15 is a physiological appetite and body weight regulator.
Tsai VW, Macia L, Johnen H, Kuffner T, Manadhar R, Jørgensen SB, Lee-Ng KK, Zhang HP, Wu L, Marquis CP, Jiang L, Husaini Y, Lin S, Herzog H, Brown DA, Sainsbury A, Breit SN. Tsai VW, et al. Among authors: jorgensen sb. PLoS One. 2013;8(2):e55174. doi: 10.1371/journal.pone.0055174. Epub 2013 Feb 28. PLoS One. 2013. PMID: 23468844 Free PMC article.
Plasma GDF15 levels are similar between subjects after bariatric surgery and matched controls and are unaffected by meals.
Martinussen C, Svane MS, Bojsen-Møller KN, Jensen CZ, Kristiansen VB, Bookout AL, Jørgensen SB, Holst JJ, Wewer Albrechtsen NJ, Madsbad S, Kuhre RE. Martinussen C, et al. Among authors: jorgensen sb. Am J Physiol Endocrinol Metab. 2021 Oct 1;321(4):E443-E452. doi: 10.1152/ajpendo.00190.2021. Epub 2021 Aug 9. Am J Physiol Endocrinol Metab. 2021. PMID: 34370594 Free article.
GDF15 increases insulin action in the liver and adipose tissue via a β-adrenergic receptor-mediated mechanism.
Sjøberg KA, Sigvardsen CM, Alvarado-Diaz A, Andersen NR, Larance M, Seeley RJ, Schjerling P, Knudsen JG, Katzilieris-Petras G, Clemmensen C, Jørgensen SB, De Bock K, Richter EA. Sjøberg KA, et al. Among authors: jorgensen sb. Cell Metab. 2023 Aug 8;35(8):1327-1340.e5. doi: 10.1016/j.cmet.2023.06.016. Epub 2023 Jul 19. Cell Metab. 2023. PMID: 37473755 Free article.
102 results