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Targeting p130Cas- and microtubule-dependent MYC regulation sensitizes pancreatic cancer to ERK MAPK inhibition.
Waters AM, Khatib TO, Papke B, Goodwin CM, Hobbs GA, Diehl JN, Yang R, Edwards AC, Walsh KH, Sulahian R, McFarland JM, Kapner KS, Gilbert TSK, Stalnecker CA, Javaid S, Barkovskaya A, Grover KR, Hibshman PS, Blake DR, Schaefer A, Nowak KM, Klomp JE, Hayes TK, Kassner M, Tang N, Tanaseichuk O, Chen K, Zhou Y, Kalkat M, Herring LE, Graves LM, Penn LZ, Yin HH, Aguirre AJ, Hahn WC, Cox AD, Der CJ. Waters AM, et al. Among authors: blake dr. Cell Rep. 2021 Jun 29;35(13):109291. doi: 10.1016/j.celrep.2021.109291. Cell Rep. 2021. PMID: 34192548 Free PMC article.
KRAS Suppression-Induced Degradation of MYC Is Antagonized by a MEK5-ERK5 Compensatory Mechanism.
Vaseva AV, Blake DR, Gilbert TSK, Ng S, Hostetter G, Azam SH, Ozkan-Dagliyan I, Gautam P, Bryant KL, Pearce KH, Herring LE, Han H, Graves LM, Witkiewicz AK, Knudsen ES, Pecot CV, Rashid N, Houghton PJ, Wennerberg K, Cox AD, Der CJ. Vaseva AV, et al. Among authors: blake dr. Cancer Cell. 2018 Nov 12;34(5):807-822.e7. doi: 10.1016/j.ccell.2018.10.001. Cancer Cell. 2018. PMID: 30423298 Free PMC article.
The KRAS-regulated kinome identifies WEE1 and ERK coinhibition as a potential therapeutic strategy in KRAS-mutant pancreatic cancer.
Diehl JN, Klomp JE, Snare KR, Hibshman PS, Blake DR, Kaiser ZD, Gilbert TSK, Baldelli E, Pierobon M, Papke B, Yang R, Hodge RG, Rashid NU, Petricoin EF 3rd, Herring LE, Graves LM, Cox AD, Der CJ. Diehl JN, et al. Among authors: blake dr. J Biol Chem. 2021 Nov;297(5):101335. doi: 10.1016/j.jbc.2021.101335. Epub 2021 Oct 22. J Biol Chem. 2021. PMID: 34688654 Free PMC article.
Gain-of-Function RHOA Mutations Promote Focal Adhesion Kinase Activation and Dependency in Diffuse Gastric Cancer.
Zhang H, Schaefer A, Wang Y, Hodge RG, Blake DR, Diehl JN, Papageorge AG, Stachler MD, Liao J, Zhou J, Wu Z, Akarca FG, de Klerk LK, Derks S, Pierobon M, Hoadley KA, Wang TC, Church G, Wong KK, Petricoin EF, Cox AD, Lowy DR, Der CJ, Bass AJ. Zhang H, et al. Among authors: blake dr. Cancer Discov. 2020 Feb;10(2):288-305. doi: 10.1158/2159-8290.CD-19-0811. Epub 2019 Nov 26. Cancer Discov. 2020. PMID: 31771969 Free PMC article.
Lamellipodia are crucial for haptotactic sensing and response.
King SJ, Asokan SB, Haynes EM, Zimmerman SP, Rotty JD, Alb JG Jr, Tagliatela A, Blake DR, Lebedeva IP, Marston D, Johnson HE, Parsons M, Sharpless NE, Kuhlman B, Haugh JM, Bear JE. King SJ, et al. Among authors: blake dr. J Cell Sci. 2016 Jun 15;129(12):2329-42. doi: 10.1242/jcs.184507. Epub 2016 May 12. J Cell Sci. 2016. PMID: 27173494 Free PMC article.
Evolution of Reactive Organic Compounds and Their Potential Health Risk in Wildfire Smoke.
Pye HOT, Xu L, Henderson BH, Pagonis D, Campuzano-Jost P, Guo H, Jimenez JL, Allen C, Skipper TN, Halliday HS, Murphy BN, D'Ambro EL, Wennberg PO, Place BK, Wiser FC, McNeill VF, Apel EC, Blake DR, Coggon MM, Crounse JD, Gilman JB, Gkatzelis GI, Hanisco TF, Huey LG, Katich JM, Lamplugh A, Lindaas J, Peischl J, St Clair JM, Warneke C, Wolfe GM, Womack C. Pye HOT, et al. Among authors: blake dr. Environ Sci Technol. 2024 Nov 5;58(44):19785-19796. doi: 10.1021/acs.est.4c06187. Epub 2024 Oct 22. Environ Sci Technol. 2024. PMID: 39436375
Chemical Analysis of Exhaled Vape Emissions: Unraveling the Complexities of Humectant Fragmentation in a Human Trial Study.
Hopstock KS, Perraud V, Dalton AB, Barletta B, Meinardi S, Weltman RM, Mirkhanian MA, Rakosi KJ, Blake DR, Edwards RD, Nizkorodov SA. Hopstock KS, et al. Among authors: blake dr. Chem Res Toxicol. 2024 Jun 17;37(6):1000-1010. doi: 10.1021/acs.chemrestox.4c00088. Epub 2024 May 20. Chem Res Toxicol. 2024. PMID: 38769630 Free PMC article.
442 results