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Impaired Right Ventricular Calcium Cycling Is an Early Risk Factor in R14del-Phospholamban Arrhythmias.
Haghighi K, Gardner G, Vafiadaki E, Kumar M, Green LC, Ma J, Crocker JS, Koch S, Arvanitis DA, Bidwell P, Rubinstein J, van de Leur R, Doevendans PA, Akar FG, Tranter M, Wang HS, Sadayappan S, DeMazumder D, Sanoudou D, Hajjar RJ, Stillitano F, Kranias EG. Haghighi K, et al. Among authors: akar fg. J Pers Med. 2021 Jun 3;11(6):502. doi: 10.3390/jpm11060502. J Pers Med. 2021. PMID: 34204946 Free PMC article.
Gene therapies for arrhythmias in heart failure.
Akar FG, Hajjar RJ. Akar FG, et al. Pflugers Arch. 2014 Jun;466(6):1211-7. doi: 10.1007/s00424-014-1485-3. Epub 2014 Feb 26. Pflugers Arch. 2014. PMID: 24566976 Free PMC article. Review.
Arrhythmia Mechanism and Dynamics in a Humanized Mouse Model of Inherited Cardiomyopathy Caused by Phospholamban R14del Mutation.
Raad N, Bittihn P, Cacheux M, Jeong D, Ilkan Z, Ceholski D, Kohlbrenner E, Zhang L, Cai CL, Kranias EG, Hajjar RJ, Stillitano F, Akar FG. Raad N, et al. Among authors: akar fg. Circulation. 2021 Aug 10;144(6):441-454. doi: 10.1161/CIRCULATIONAHA.119.043502. Epub 2021 May 24. Circulation. 2021. PMID: 34024116 Free PMC article.
Gene editing reverses arrhythmia susceptibility in humanized PLN-R14del mice: modelling a European cardiomyopathy with global impact.
Dave J, Raad N, Mittal N, Zhang L, Fargnoli A, Oh JG, Savoia ME, Hansen J, Fava M, Yin X, Theofilatos K, Ceholski D, Kohlbrenner E, Jeong D, Wills L, Nonnenmacher M, Haghighi K, Costa KD, Turnbull IC, Mayr M, Cai CL, Kranias EG, Akar FG, Hajjar RJ, Stillitano F. Dave J, et al. Among authors: akar fg. Cardiovasc Res. 2022 Dec 9;118(15):3140-3150. doi: 10.1093/cvr/cvac021. Cardiovasc Res. 2022. PMID: 35191471 Free PMC article.
Intra-tracheal gene delivery of aerosolized SERCA2a to the lung suppresses ventricular arrhythmias in a model of pulmonary arterial hypertension.
Strauss B, Sassi Y, Bueno-Beti C, Ilkan Z, Raad N, Cacheux M, Bisserier M, Turnbull IC, Kohlbrenner E, Hajjar RJ, Hadri L, Akar FG. Strauss B, et al. Among authors: akar fg. J Mol Cell Cardiol. 2019 Feb;127:20-30. doi: 10.1016/j.yjmcc.2018.11.017. Epub 2018 Nov 28. J Mol Cell Cardiol. 2019. PMID: 30502350 Free PMC article.
114 results