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ALKBH3 partner ASCC3 mediates P-body formation and selective clearance of MMS-induced 1-methyladenosine and 3-methylcytosine from mRNA.
Wollen KL, Hagen L, Vågbø CB, Rabe R, Iveland TS, Aas PA, Sharma A, Sporsheim B, Erlandsen HO, Palibrk V, Bjørås M, Fonseca DM, Mosammaparast N, Slupphaug G. Wollen KL, et al. Among authors: mosammaparast n. J Transl Med. 2021 Jul 3;19(1):287. doi: 10.1186/s12967-021-02948-6. J Transl Med. 2021. PMID: 34217309 Free PMC article.
A ubiquitin-dependent signalling axis specific for ALKBH-mediated DNA dealkylation repair.
Brickner JR, Soll JM, Lombardi PM, Vågbø CB, Mudge MC, Oyeniran C, Rabe R, Jackson J, Sullender ME, Blazosky E, Byrum AK, Zhao Y, Corbett MA, Gécz J, Field M, Vindigni A, Slupphaug G, Wolberger C, Mosammaparast N. Brickner JR, et al. Among authors: mosammaparast n. Nature. 2017 Nov 16;551(7680):389-393. doi: 10.1038/nature24484. Epub 2017 Nov 8. Nature. 2017. PMID: 29144457 Free PMC article.
Aberrant RNA methylation triggers recruitment of an alkylation repair complex.
Tsao N, Brickner JR, Rodell R, Ganguly A, Wood M, Oyeniran C, Ahmad T, Sun H, Bacolla A, Zhang L, Lukinović V, Soll JM, Townley BA, Casanova AG, Tainer JA, He C, Vindigni A, Reynoird N, Mosammaparast N. Tsao N, et al. Among authors: mosammaparast n. Mol Cell. 2021 Oct 21;81(20):4228-4242.e8. doi: 10.1016/j.molcel.2021.09.024. Mol Cell. 2021. PMID: 34686315 Free PMC article.
The histone demethylase LSD1/KDM1A promotes the DNA damage response.
Mosammaparast N, Kim H, Laurent B, Zhao Y, Lim HJ, Majid MC, Dango S, Luo Y, Hempel K, Sowa ME, Gygi SP, Steen H, Harper JW, Yankner B, Shi Y. Mosammaparast N, et al. J Cell Biol. 2013 Nov 11;203(3):457-70. doi: 10.1083/jcb.201302092. J Cell Biol. 2013. PMID: 24217620 Free PMC article.
The ASCC2 CUE domain in the ALKBH3-ASCC DNA repair complex recognizes adjacent ubiquitins in K63-linked polyubiquitin.
Lombardi PM, Haile S, Rusanov T, Rodell R, Anoh R, Baer JG, Burke KA, Gray LN, Hacker AR, Kebreau KR, Ngandu CK, Orland HA, Osei-Asante E, Schmelyun DP, Shorb DE, Syed SH, Veilleux JM, Majumdar A, Mosammaparast N, Wolberger C. Lombardi PM, et al. Among authors: mosammaparast n. J Biol Chem. 2022 Feb;298(2):101545. doi: 10.1016/j.jbc.2021.101545. Epub 2021 Dec 28. J Biol Chem. 2022. PMID: 34971705 Free PMC article.
63 results