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Page 1
Controlling Intramolecular Interactions in the Design of Selective, High-Affinity Ligands for the CREBBP Bromodomain.
Brand M, Clayton J, Moroglu M, Schiedel M, Picaud S, Bluck JP, Skwarska A, Bolland H, Chan AKN, Laurin CMC, Scorah AR, See L, Rooney TPC, Andrews KH, Fedorov O, Perell G, Kalra P, Vinh KB, Cortopassi WA, Heitel P, Christensen KE, Cooper RI, Paton RS, Pomerantz WCK, Biggin PC, Hammond EM, Filippakopoulos P, Conway SJ. Brand M, et al. Among authors: clayton j. J Med Chem. 2021 Jul 22;64(14):10102-10123. doi: 10.1021/acs.jmedchem.1c00348. Epub 2021 Jul 13. J Med Chem. 2021. PMID: 34255515 Free PMC article.
BET bromodomain ligands: Probing the WPF shelf to improve BRD4 bromodomain affinity and metabolic stability.
Jennings LE, Schiedel M, Hewings DS, Picaud S, Laurin CMC, Bruno PA, Bluck JP, Scorah AR, See L, Reynolds JK, Moroglu M, Mistry IN, Hicks A, Guzanov P, Clayton J, Evans CNG, Stazi G, Biggin PC, Mapp AK, Hammond EM, Humphreys PG, Filippakopoulos P, Conway SJ. Jennings LE, et al. Among authors: clayton j. Bioorg Med Chem. 2018 Jul 15;26(11):2937-2957. doi: 10.1016/j.bmc.2018.05.003. Epub 2018 May 15. Bioorg Med Chem. 2018. PMID: 29776834 Free article.
Covalent Chemical Cochaperones of the p300/CBP GACKIX Domain.
Lodge JM, Majmudar CY, Clayton J, Mapp AK. Lodge JM, et al. Among authors: clayton j. Chembiochem. 2018 Sep 17;19(18):1907-1912. doi: 10.1002/cbic.201800173. Epub 2018 Sep 5. Chembiochem. 2018. PMID: 29939485 Free PMC article.
Carbocyclic analogs of guanosine and 8-azaguanosine.
Shealy YF, Clayton JD. Shealy YF, et al. Among authors: clayton jd. J Pharm Sci. 1973 Sep;62(9):1432-4. doi: 10.1002/jps.2600620907. J Pharm Sci. 1973. PMID: 4743086 No abstract available.
Benzene analogs of triazenoimidazoles.
Shealy YF, O'Dell CA, Clayton JD, Krauth CA. Shealy YF, et al. Among authors: clayton jd. J Pharm Sci. 1971 Sep;60(9):1426-8. doi: 10.1002/jps.2600600934. J Pharm Sci. 1971. PMID: 5105894 No abstract available.
837 results