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A loss-of-function variant in SUV39H2 identified in autism-spectrum disorder causes altered H3K9 trimethylation and dysregulation of protocadherin β-cluster genes in the developing brain.
Balan S, Iwayama Y, Ohnishi T, Fukuda M, Shirai A, Yamada A, Weirich S, Schuhmacher MK, Dileep KV, Endo T, Hisano Y, Kotoshiba K, Toyota T, Otowa T, Kuwabara H, Tochigi M, Watanabe A, Ohba H, Maekawa M, Toyoshima M, Sasaki T, Nakamura K, Tsujii M, Matsuzaki H, Zhang KYJ, Jeltsch A, Shinkai Y, Yoshikawa T. Balan S, et al. Among authors: hisano y. Mol Psychiatry. 2021 Dec;26(12):7550-7559. doi: 10.1038/s41380-021-01199-7. Epub 2021 Jul 15. Mol Psychiatry. 2021. PMID: 34262135
Functional characterization of FABP3, 5 and 7 gene variants identified in schizophrenia and autism spectrum disorder and mouse behavioral studies.
Shimamoto C, Ohnishi T, Maekawa M, Watanabe A, Ohba H, Arai R, Iwayama Y, Hisano Y, Toyota T, Toyoshima M, Suzuki K, Shirayama Y, Nakamura K, Mori N, Owada Y, Kobayashi T, Yoshikawa T. Shimamoto C, et al. Among authors: hisano y. Hum Mol Genet. 2014 Dec 15;23(24):6495-511. doi: 10.1093/hmg/ddu369. Epub 2014 Jul 15. Hum Mol Genet. 2014. PMID: 25027319 Free PMC article.
Investigation of the fatty acid transporter-encoding genes SLC27A3 and SLC27A4 in autism.
Maekawa M, Iwayama Y, Ohnishi T, Toyoshima M, Shimamoto C, Hisano Y, Toyota T, Balan S, Matsuzaki H, Iwata Y, Takagai S, Yamada K, Ota M, Fukuchi S, Okada Y, Akamatsu W, Tsujii M, Kojima N, Owada Y, Okano H, Mori N, Yoshikawa T. Maekawa M, et al. Among authors: hisano y. Sci Rep. 2015 Nov 9;5:16239. doi: 10.1038/srep16239. Sci Rep. 2015. PMID: 26548558 Free PMC article.
A potential role of fatty acid binding protein 4 in the pathophysiology of autism spectrum disorder.
Maekawa M, Ohnishi T, Toyoshima M, Shimamoto-Mitsuyama C, Hamazaki K, Balan S, Wada Y, Esaki K, Takagai S, Tsuchiya KJ, Nakamura K, Iwata Y, Nara T, Iwayama Y, Toyota T, Nozaki Y, Ohba H, Watanabe A, Hisano Y, Matsuoka S, Tsujii M, Mori N, Matsuzaki H, Yoshikawa T. Maekawa M, et al. Among authors: hisano y. Brain Commun. 2020 Sep 10;2(2):fcaa145. doi: 10.1093/braincomms/fcaa145. eCollection 2020. Brain Commun. 2020. PMID: 33225276 Free PMC article.
Peroxisome proliferator-activated receptor α as a novel therapeutic target for schizophrenia.
Wada Y, Maekawa M, Ohnishi T, Balan S, Matsuoka S, Iwamoto K, Iwayama Y, Ohba H, Watanabe A, Hisano Y, Nozaki Y, Toyota T, Shimogori T, Itokawa M, Kobayashi T, Yoshikawa T. Wada Y, et al. Among authors: hisano y. EBioMedicine. 2020 Dec;62:103130. doi: 10.1016/j.ebiom.2020.103130. Epub 2020 Dec 2. EBioMedicine. 2020. PMID: 33279456 Free PMC article.
Analysis of induced pluripotent stem cells carrying 22q11.2 deletion.
Toyoshima M, Akamatsu W, Okada Y, Ohnishi T, Balan S, Hisano Y, Iwayama Y, Toyota T, Matsumoto T, Itasaka N, Sugiyama S, Tanaka M, Yano M, Dean B, Okano H, Yoshikawa T. Toyoshima M, et al. Among authors: hisano y. Transl Psychiatry. 2016 Nov 1;6(11):e934. doi: 10.1038/tp.2016.206. Transl Psychiatry. 2016. PMID: 27801899 Free PMC article.
Polyunsaturated fatty acid deficiency during neurodevelopment in mice models the prodromal state of schizophrenia through epigenetic changes in nuclear receptor genes.
Maekawa M, Watanabe A, Iwayama Y, Kimura T, Hamazaki K, Balan S, Ohba H, Hisano Y, Nozaki Y, Ohnishi T, Toyoshima M, Shimamoto C, Iwamoto K, Bundo M, Osumi N, Takahashi E, Takashima A, Yoshikawa T. Maekawa M, et al. Among authors: hisano y. Transl Psychiatry. 2017 Sep 5;7(9):e1229. doi: 10.1038/tp.2017.182. Transl Psychiatry. 2017. PMID: 28872641 Free PMC article.
Investigation of betaine as a novel psychotherapeutic for schizophrenia.
Ohnishi T, Balan S, Toyoshima M, Maekawa M, Ohba H, Watanabe A, Iwayama Y, Fujita Y, Tan Y, Hisano Y, Shimamoto-Mitsuyama C, Nozaki Y, Esaki K, Nagaoka A, Matsumoto J, Hino M, Mataga N, Hayashi-Takagi A, Hashimoto K, Kunii Y, Kakita A, Yabe H, Yoshikawa T. Ohnishi T, et al. Among authors: hisano y. EBioMedicine. 2019 Jul;45:432-446. doi: 10.1016/j.ebiom.2019.05.062. Epub 2019 Jun 26. EBioMedicine. 2019. PMID: 31255657 Free PMC article.
90 results