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Astrocytic interleukin-3 programs microglia and limits Alzheimer's disease.
McAlpine CS, Park J, Griciuc A, Kim E, Choi SH, Iwamoto Y, Kiss MG, Christie KA, Vinegoni C, Poller WC, Mindur JE, Chan CT, He S, Janssen H, Wong LP, Downey J, Singh S, Anzai A, Kahles F, Jorfi M, Feruglio PF, Sadreyev RI, Weissleder R, Kleinstiver BP, Nahrendorf M, Tanzi RE, Swirski FK. McAlpine CS, et al. Among authors: kleinstiver bp. Nature. 2021 Jul;595(7869):701-706. doi: 10.1038/s41586-021-03734-6. Epub 2021 Jul 14. Nature. 2021. PMID: 34262178 Free PMC article.
Base editing strategies to convert CAG to CAA diminish the disease-causing mutation in Huntington's disease.
Choi DE, Shin JW, Zeng S, Hong EP, Jang JH, Loupe JM, Wheeler VC, Stutzman HE, Kleinstiver BP, Lee JM. Choi DE, et al. Among authors: kleinstiver bp. bioRxiv [Preprint]. 2023 Apr 28:2023.04.28.538700. doi: 10.1101/2023.04.28.538700. bioRxiv. 2023. Update in: Elife. 2024 Jun 13;12:RP89782. doi: 10.7554/eLife.89782 PMID: 37162872 Free PMC article. Updated. Preprint.
PAM-Flexible Genome Editing with an Engineered Chimeric Cas9.
Koseki S, Hong L, Yudistyra V, Stan T, Tysinger E, Silverstein R, Kramme C, Amrani N, Savic N, Pacesa M, Rodriguez T, Ponnapati M, Jacobson J, Church G, Truant R, Jinek M, Kleinstiver B, Sontheimer E, Chatterjee P. Koseki S, et al. Res Sq [Preprint]. 2023 Mar 7:rs.3.rs-2625838. doi: 10.21203/rs.3.rs-2625838/v1. Res Sq. 2023. Update in: Nat Commun. 2023 Oct 4;14(1):6175. doi: 10.1038/s41467-023-41829-y PMID: 36945419 Free PMC article. Updated. Preprint.
CRISPR-Cas Genome Editing in Ex Vivo Human Lungs to Rewire the Translational Path of Genome-Targeting Therapeutics.
Mesaki K, Yamamoto H, Juvet S, Yeung J, Guan Z, Akhter A, Yao Y, Dickie C, Mangat H, Wang A, Wilson GW, Mariscal A, Hu J, Davidson AR, Kleinstiver BP, Cypel M, Liu M, Keshavjee S. Mesaki K, et al. Among authors: kleinstiver bp. Hum Gene Ther. 2024 Jun;35(11-12):374-387. doi: 10.1089/hum.2023.223. Epub 2024 May 23. Hum Gene Ther. 2024. PMID: 38717950
CRISPR-Cas9-AAV versus lentivector transduction for genome modification of X-linked severe combined immunodeficiency hematopoietic stem cells.
Brault J, Liu T, Liu S, Lawson A, Choi U, Kozhushko N, Bzhilyanskaya V, Pavel-Dinu M, Meis RJ, Eckhaus MA, Burkett SS, Bosticardo M, Kleinstiver BP, Notarangelo LD, Lazzarotto CR, Tsai SQ, Wu X, Dahl GA, Porteus MH, Malech HL, De Ravin SS. Brault J, et al. Among authors: kleinstiver bp. Front Immunol. 2023 Jan 4;13:1067417. doi: 10.3389/fimmu.2022.1067417. eCollection 2022. Front Immunol. 2023. PMID: 36685559 Free PMC article.
Allele-specific gene editing prevents deafness in a model of dominant progressive hearing loss.
György B, Nist-Lund C, Pan B, Asai Y, Karavitaki KD, Kleinstiver BP, Garcia SP, Zaborowski MP, Solanes P, Spataro S, Schneider BL, Joung JK, Géléoc GSG, Holt JR, Corey DP. György B, et al. Among authors: kleinstiver bp. Nat Med. 2019 Jul;25(7):1123-1130. doi: 10.1038/s41591-019-0500-9. Epub 2019 Jul 3. Nat Med. 2019. PMID: 31270503 Free PMC article.
Broad-spectrum anti-CRISPR proteins facilitate horizontal gene transfer.
Mahendra C, Christie KA, Osuna BA, Pinilla-Redondo R, Kleinstiver BP, Bondy-Denomy J. Mahendra C, et al. Among authors: kleinstiver bp. Nat Microbiol. 2020 Apr;5(4):620-629. doi: 10.1038/s41564-020-0692-2. Epub 2020 Mar 26. Nat Microbiol. 2020. PMID: 32218510 Free PMC article.
Listeria Phages Induce Cas9 Degradation to Protect Lysogenic Genomes.
Osuna BA, Karambelkar S, Mahendra C, Christie KA, Garcia B, Davidson AR, Kleinstiver BP, Kilcher S, Bondy-Denomy J. Osuna BA, et al. Among authors: kleinstiver bp. Cell Host Microbe. 2020 Jul 8;28(1):31-40.e9. doi: 10.1016/j.chom.2020.04.001. Epub 2020 Apr 22. Cell Host Microbe. 2020. PMID: 32325050 Free PMC article.
84 results