Gumpena R - Search Results

1

Dual Glycolate Oxidase/Lactate Dehydrogenase A Inhibitors for Primary Hyperoxaluria.

Ding J, Gumpena R, Boily MO, Caron A, Chong O, Cox JH, Dumais V, Gaudreault S, Graff AH, King A, Knight J, Oballa R, Surendradoss J, Tang T, Wu J, Lowther WT, Powell DA. Ding J, et al. Among authors: gumpena r. ACS Med Chem Lett. 2021 May 20;12(7):1116-1123. doi: 10.1021/acsmedchemlett.1c00196. eCollection 2021 Jul 8. ACS Med Chem Lett. 2021. PMID: 34267881 Free PMC article.

2

Specificity of Human Sulfiredoxin for Reductant and Peroxiredoxin Oligomeric State.

Forshaw TE, Reisz JA, Nelson KJ, Gumpena R, Lawson JR, Jönsson TJ, Wu H, Clodfelter JE, Johnson LC, Furdui CM, Lowther WT. Forshaw TE, et al. Among authors: gumpena r. Antioxidants (Basel). 2021 Jun 11;10(6):946. doi: 10.3390/antiox10060946. Antioxidants (Basel). 2021. PMID: 34208049 Free PMC article.

3

Identification, biochemical and structural evaluation of species-specific inhibitors against type I methionine aminopeptidases.

Kishor C, Arya T, Reddi R, Chen X, Saddanapu V, Marapaka AK, Gumpena R, Ma D, Liu JO, Addlagatta A. Kishor C, et al. Among authors: gumpena r. J Med Chem. 2013 Jul 11;56(13):5295-305. doi: 10.1021/jm400395p. Epub 2013 Jun 27. J Med Chem. 2013. PMID: 23767698

4

Identification of the molecular basis of inhibitor selectivity between the human and streptococcal type I methionine aminopeptidases.

Arya T, Reddi R, Kishor C, Ganji RJ, Bhukya S, Gumpena R, McGowan S, Drag M, Addlagatta A. Arya T, et al. Among authors: gumpena r. J Med Chem. 2015 Mar 12;58(5):2350-7. doi: 10.1021/jm501790e. Epub 2015 Feb 27. J Med Chem. 2015. PMID: 25699713

5

Selective targeting of the conserved active site cysteine of Mycobacterium tuberculosis methionine aminopeptidase with electrophilic reagents.

Reddi R, Arya T, Kishor C, Gumpena R, Ganji RJ, Bhukya S, Addlagatta A. Reddi R, et al. Among authors: gumpena r. FEBS J. 2014 Sep;281(18):4240-8. doi: 10.1111/febs.12847. Epub 2014 Jun 6. FEBS J. 2014. PMID: 24841365 Free article.

6

Structural basis for the inhibition of M1 family aminopeptidases by the natural product actinonin: Crystal structure in complex with E. coli aminopeptidase N.

Ganji RJ, Reddi R, Gumpena R, Marapaka AK, Arya T, Sankoju P, Bhukya S, Addlagatta A. Ganji RJ, et al. Among authors: gumpena r. Protein Sci. 2015 May;24(5):823-31. doi: 10.1002/pro.2653. Epub 2015 Apr 8. Protein Sci. 2015. PMID: 25644575 Free PMC article.

7

Discovery of α,β- and α,γ-diamino acid scaffolds for the inhibition of M1 family aminopeptidases.

Gumpena R, Kishor C, Ganji RJ, Addlagatta A. Gumpena R, et al. ChemMedChem. 2011 Nov 4;6(11):1971-6. doi: 10.1002/cmdc.201100298. Epub 2011 Aug 16. ChemMedChem. 2011. PMID: 22025387 No abstract available.

8

Glu121-Lys319 salt bridge between catalytic and N-terminal domains is pivotal for the activity and stability of Escherichia coli aminopeptidase N.

Gumpena R, Kishor C, Ganji RJ, Jain N, Addlagatta A. Gumpena R, et al. Protein Sci. 2012 May;21(5):727-36. doi: 10.1002/pro.2060. Epub 2012 Mar 30. Protein Sci. 2012. PMID: 22411732 Free PMC article.

9

Discovery, Structural and Biochemical Studies of a rare Glu/Asp Specific M1 Class Aminopeptidase from Legionella pneumophila.

Marapaka AK, Pillalamarri V, Gumpena R, Haque N, Bala SC, Jangam A, Addlagatta A. Marapaka AK, et al. Among authors: gumpena r. Int J Biol Macromol. 2018 Dec;120(Pt A):1111-1118. doi: 10.1016/j.ijbiomac.2018.08.172. Epub 2018 Aug 30. Int J Biol Macromol. 2018. PMID: 30172821

10

Crystal structure of the human dual specificity phosphatase 1 catalytic domain.

Gumpena R, Lountos GT, Raran-Kurussi S, Tropea JE, Cherry S, Waugh DS. Gumpena R, et al. Protein Sci. 2018 Feb;27(2):561-567. doi: 10.1002/pro.3328. Epub 2017 Nov 21. Protein Sci. 2018. PMID: 29052270 Free PMC article.

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