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Dual Glycolate Oxidase/Lactate Dehydrogenase A Inhibitors for Primary Hyperoxaluria.
Ding J, Gumpena R, Boily MO, Caron A, Chong O, Cox JH, Dumais V, Gaudreault S, Graff AH, King A, Knight J, Oballa R, Surendradoss J, Tang T, Wu J, Lowther WT, Powell DA. Ding J, et al. Among authors: lowther wt. ACS Med Chem Lett. 2021 May 20;12(7):1116-1123. doi: 10.1021/acsmedchemlett.1c00196. eCollection 2021 Jul 8. ACS Med Chem Lett. 2021. PMID: 34267881 Free PMC article.
The effects of the inactivation of Hydroxyproline dehydrogenase on urinary oxalate and glycolate excretion in mouse models of primary hyperoxaluria.
Buchalski B, Wood KD, Challa A, Fargue S, Holmes RP, Lowther WT, Knight J. Buchalski B, et al. Among authors: lowther wt. Biochim Biophys Acta Mol Basis Dis. 2020 Mar 1;1866(3):165633. doi: 10.1016/j.bbadis.2019.165633. Epub 2019 Dec 7. Biochim Biophys Acta Mol Basis Dis. 2020. PMID: 31821850 Free PMC article.
Hydroxyproline Metabolism and Oxalate Synthesis in Primary Hyperoxaluria.
Fargue S, Milliner DS, Knight J, Olson JB, Lowther WT, Holmes RP. Fargue S, et al. Among authors: lowther wt. J Am Soc Nephrol. 2018 Jun;29(6):1615-1623. doi: 10.1681/ASN.2017040390. Epub 2018 Mar 27. J Am Soc Nephrol. 2018. PMID: 29588429 Free PMC article.
Novel hyperoxidation resistance motifs in 2-Cys peroxiredoxins.
Bolduc JA, Nelson KJ, Haynes AC, Lee J, Reisz JA, Graff AH, Clodfelter JE, Parsonage D, Poole LB, Furdui CM, Lowther WT. Bolduc JA, et al. Among authors: lowther wt. J Biol Chem. 2018 Jul 27;293(30):11901-11912. doi: 10.1074/jbc.RA117.001690. Epub 2018 Jun 8. J Biol Chem. 2018. PMID: 29884768 Free PMC article.
Specificity of Human Sulfiredoxin for Reductant and Peroxiredoxin Oligomeric State.
Forshaw TE, Reisz JA, Nelson KJ, Gumpena R, Lawson JR, Jönsson TJ, Wu H, Clodfelter JE, Johnson LC, Furdui CM, Lowther WT. Forshaw TE, et al. Among authors: lowther wt. Antioxidants (Basel). 2021 Jun 11;10(6):946. doi: 10.3390/antiox10060946. Antioxidants (Basel). 2021. PMID: 34208049 Free PMC article.
End Points for Clinical Trials in Primary Hyperoxaluria.
Milliner DS, McGregor TL, Thompson A, Dehmel B, Knight J, Rosskamp R, Blank M, Yang S, Fargue S, Rumsby G, Groothoff J, Allain M, West M, Hollander K, Lowther WT, Lieske JC. Milliner DS, et al. Among authors: lowther wt. Clin J Am Soc Nephrol. 2020 Jul 1;15(7):1056-1065. doi: 10.2215/CJN.13821119. Epub 2020 Mar 12. Clin J Am Soc Nephrol. 2020. PMID: 32165440 Free PMC article.
65 results