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TVB-2640 (FASN Inhibitor) for the Treatment of Nonalcoholic Steatohepatitis: FASCINATE-1, a Randomized, Placebo-Controlled Phase 2a Trial.
Loomba R, Mohseni R, Lucas KJ, Gutierrez JA, Perry RG, Trotter JF, Rahimi RS, Harrison SA, Ajmera V, Wayne JD, O'Farrell M, McCulloch W, Grimmer K, Rinella M, Wai-Sun Wong V, Ratziu V, Gores GJ, Neuschwander-Tetri BA, Kemble G. Loomba R, et al. Among authors: gutierrez ja. Gastroenterology. 2021 Nov;161(5):1475-1486. doi: 10.1053/j.gastro.2021.07.025. Epub 2021 Jul 23. Gastroenterology. 2021. PMID: 34310978 Free article. Clinical Trial.
Endogenously produced itaconate negatively regulates innate-driven cytokine production and drives global ubiquitination in human macrophages.
Bourner LA, Chung LA, Long H, McGettrick AF, Xiao J, Roth K, Bailey JD, Strickland M, Tan B, Cunningham J, Lutzke B, McGee J, Otero FJ, Gemperline DC, Zhang L, Wang YC, Chalmers MJ, Yang CW, Gutierrez JA, O'Neill LAJ, Dorsey FC. Bourner LA, et al. Among authors: gutierrez ja. Cell Rep. 2024 Aug 27;43(8):114570. doi: 10.1016/j.celrep.2024.114570. Epub 2024 Aug 1. Cell Rep. 2024. PMID: 39093697 Free article.
Characterization of peripheral artery disease and associations with traditional risk factors, mobility, and biomarkers in the project baseline health study.
Kercheval JB, Narcisse DI, Nguyen M, Rao SV, Gutierrez JA, Leeper NJ, Maron DJ, Rodriguez F, Hernandez AF, Mahaffey KW, Shah SH, Swaminathan RV; Project Baseline Health Study Group. Kercheval JB, et al. Among authors: gutierrez ja. Am Heart J. 2024 Sep;275:183-190. doi: 10.1016/j.ahj.2024.06.010. Epub 2024 Jul 3. Am Heart J. 2024. PMID: 38969081
321 results